◀ Back to PTGS2

PTGS2 — SRC

Text-mined interactions from Literome

Vogel et al., Carcinogenesis 2000 : The experimental data presented in this article reveal a XRE independent and c-Src mediated activation of the PGHS-2 gene by TCDD through the C/EBP response element located in its promoter region
Kim et al., J Invest Dermatol 2004 (MAP Kinase Signaling System) : These results suggest that IGF-II induces COX-2 expression through the tyrosine kinase-Src-ERK and tyrosine kinase-PI3-kinase pathways, but not via p38 MAPK pathway, and that the basal JNK activity is required for the upregulation of COX-2 by IGF-II, as well
Park et al., Int J Biochem Cell Biol 2004 (Bone Resorption) : A novel Src tyrosine kinase inhibitor, Herbimycin A ( HERB ), reduced COX-2 mRNA levels as well as PGE ( 2 ) production induced by IL-1beta, TNF-alpha and IL-6 or a combination of IL-1beta, TNF-alpha, IL-6, whereas COX-1 mRNA levels remained unaffected
Chang et al., Mol Pharmacol 2004 : Induction of cyclooxygenase-2 overexpression in human gastric epithelial cells by Helicobacter pylori involves TLR2/TLR9 and c-Src dependent nuclear factor-kappaB activation ... Phosphatidylinositol-specific phospholipase C ( PI-PLC ), protein kinase C ( PKC ), and Src inhibitors inhibited COX-2 induction
Zaric et al., J Biol Chem 2005 : Adhesion induced COX-2 expression was strongly suppressed by pharmacological inhibition of c-Src , phosphatidylinositol 3-kinase, p38, extracellular regulated kinase 1/2, and, to a lesser extent, protein kinase C and by the inhibition of mRNA or protein synthesis
Chen et al., Mol Biol Cell 2005 : MG132 induced DNA binding activity of C/EBPdelta, but not C/EBPbeta was regulated by p38, PI3K, Src , and protein kinase C. Small interfering RNA of C/EBPdelta suppressed COX-2 expression, further strengthening the role of C/EBPdelta in COX-2 gene transcription
Han et al., J Biol Chem 2006 : In parallel, activation of COX-2/PGE ( 2 ) signaling also enhances Stat3 phosphorylation and reporter activity through EP ( 1 ) receptor induced activation of c-Src and EGFR in these cells
Shen et al., J Mol Cell Cardiol 2007 : Furthermore, activation of PLCgamma1 is a consequence of the Src family activation since inhibition of Src abrogated whereas over-expression of Src enhanced PLCgamma1 phosphorylation and COX-2 expression in LPS stimulated cardiomyocytes
Hsieh et al., Biochim Biophys Acta 2008 : Moreover, thrombin stimulated activation of NF-kappaB, AP-1, and COX-2 promoter activity was blocked by the inhibitors of c-Src , PKC, EGFR, MEK1/2, AP-1 and NF-kappaB, suggesting that thrombin induces COX-2 promoter activity mediated through PKC ( delta ) /c-Src dependent EGFR transactivation, MEK-ERK1/2, AP-1, and NF-kappaB
Collins et al., J Cell Mol Med 2009 : SRC was concentration-dependently inhibited by selective COX-1 ( SC-560 and FR-122047 ) and COX-2 inhibitors ( NS-398 and LM-1685 ), and by SC-51089, a selective antagonist for the PGE-2 receptor ( EP ) and ICI-192,605 and SQ-29,548, selective antagonists for thromboxane receptors ( TP )
Husvik et al., Eur J Oral Sci 2009 (Carcinoma, Basosquamous...) : Neither the transcription factor nuclear factor-kappaB (NF-kappaB), nor Src , was involved in EGF induced COX-2 expression
Frey et al., Lab Invest 2010 (Colonic Neoplasms) : ErbB4 stimulated COX-2 induction was associated with an increase in mRNA half-life and was blocked by inhibition of Src , phosphatidylinositol (PI) 3-kinase, or epidermal growth factor receptor (EGFR)
Lee et al., Biochem Pharmacol 2010 : Kaempferol inhibits UVB induced COX-2 expression by suppressing Src kinase activity
Hirota et al., Am J Physiol Gastrointest Liver Physiol 2012 : However, inhibition of either Src tyrosine kinase signaling by PP2, Rho kinase signaling by Y27632, or phosphatidylinositol 3 (PI3) kinase signaling by LY294002 prevented 2fLI induced COX-2 expression
McElroy et al., PloS one 2012 : LPS induction of COX-2 requires Src-family kinase signaling while LPS transactivation of EGFR requires matrix metalloprotease ( MMP ) activity
Subbaramaiah et al., Cancer Res 1996 (Cell Transformation, Neoplastic...) : Src mediated up-regulation of Cox-2 promoter activity was suppressed by dominant negative ras