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MYLIP — PGP
Text-mined interactions from Literome
Bao et al., Am J Pathol 2012
(Breast Neoplasms...) :
Furthermore, down-regulation of
miR-298 increased
P-gp expression and induced doxorubicin resistance in sensitive breast cancer cells
Ikemura et al., Mol Pharmacol 2013
(Reperfusion Injury) :
The downregulation of
miR-145 in Caco-2 cells, an epithelial cell line derived from human colon,
increased P-gp expression and efflux activity of rhodamine 123, but not MDR1 mRNA level ... These findings demonstrated that
miR-145 negatively
regulates the expression and function of
P-gp through the repression of mRNA by direct interaction on the 3'-UTR of MDR1 mRNA ... In addition, the downregulation of
miR-145 should significantly
contribute to the elevated intestinal
P-gp expression after liver I/R
Zhu et al., Acta Biochim Biophys Sin (Shanghai) 2013
(Neoplasms, Experimental) :
Moreover, elevated expression of
miR-137 reduced the protein expression levels of YB-1 and
P-gp , mimicking the effect of YB-1 knockdown in the sensitivity of MCF-7/ADM cells to anticancer agents, whereas restoration of YB-1 diminished this effect