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IL8 — PGD

Text-mined interactions from Literome

Chiba et al., Int Arch Allergy Immunol 2006 : We demonstrated that PGD ( 2 ) induced production of IL-8 and GM-CSF in NCI-H ( 292 ) and NHBE cells ... These results suggest that PGD ( 2 ) is a potent inducer of IL-8 and GM-CSF production with MAP/ERK and p38 MAP kinase activation, but this is independent of CRTH2 activation
Hirano et al., Eur J Pharmacol 2007 : Synergistic effect of PGD2 via prostanoid DP receptor on TNF-alpha induced production of MCP-1 and IL-8 in human monocytic THP-1 cells ... In the present study, to clarify the functional roles of prostanoid DP receptor on monocytes, we examined the effect of PGD2 on the production of monocyte chemoattractant protein (MCP)-1 and interleukin (IL)-8 from a human monocytic cell line, THP-1 ... In addition, the selective prostanoid DP receptor antagonist, pinagladin ( ( Z ) -7- [ ( 1R,2R,3S,5S ) -2- ( benzothiophen-3-ylcarbonylamide ) -10-norpinan-3-yl ] hept-5-enoic acid ) inhibited the production of MCP-1 and IL-8 upon combined stimulation with PGD2 and TNF-alpha
Chiba et al., Int Arch Allergy Immunol 2009 : Although our studies have shown that PGD2 ( metabolic precursor of 15d-PGJ2 ) induces IL-8 and GM-CSF production, the role of 15d-PGJ2 ( metabolite of PGD2 ) is unknown in human bronchial epithelial cells