Gene interactions and pathways from curated databases and text-mining

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BCL2 — TXN

Text-mined interactions from Literome

Andoh et al., J Biol Chem 2003 : The activated PKG is required to protect cells from lipid peroxidation and apoptosis, to inhibit caspase-9 and caspase-3 activation, and to elevate the levels of Trx peroxidase-1 and Trx , which subsequently induces the expression of Bcl-2
Andoh et al., Mol Pharmacol 2005 : We have observed that thioredoxin (Trx) mediates the induction of mitochondrial manganese superoxide dismutase ( MnSOD ) and Bcl-2 during preconditioning induced hormesis ... Trx ( 1 microM ) consistently increased the expression of mitochondrial proteins MnSOD and Bcl-2 , supporting cell survival ( Andoh et al., 2002 )
Wang et al., J Biol Chem 2006 : The down-regulation of Trx2 expression caused a decrease in the protein level of Bcl-xL on day 3, whereas the protein level of Bcl-2 did not change until day 4, and the mRNA level of Bcl-xL was unchanged