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ITGA5 — MAPK3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MAPK3 → Complex of ITGA5-ITGB1 (increases, ITGA5/ITGB1 Activity) Bao et al., Mol Cell Biol 2002*
  Evidence: Cell attachment to fibronectin through ITGA5.ITGB1 activated the phosphorylation of ERK-1 within 60 minutes. ERK-1 activation was detected even in the presence of dn Cdc42 or dn Rac1 after attachment to fibronectin, indicating that these integrin-induced signaling components are still activated by attachment when Cdc42 and Rac1 are blocked.

Text-mined interactions from Literome

Qiang et al., Exp Hematol 2000 : Activation of mitogen activated protein kinase through alpha5/beta1 integrin is required for cell cycle progression of B progenitor cell line, Reh, on human marrow stromal cells
Chen et al., Zhonghua Wai Ke Za Zhi 2006 (Prostatic Neoplasms) : Using flow-cytometry, the effects of EGF and the mitogen activated protein kinase ( MAPK ) signal pathway inhibitor PD98059 on the expression of integrin alpha5 and beta1 subunits on DU145 cell surface were analyzed
Camacho-Leal et al., J Cell Physiol 2007 (MAP Kinase Signaling System) : Inhibition of PI3-K and ILK, but not MAPK , prevented the alpha5beta1 integrin activation
Pandolfi et al., J Cell Physiol 2007 (Kidney Failure, Chronic...) : Interestingly, ESRD-RBC induced increased expression of adhesion molecules was prevented by Annexin-V ( AnV, able to mask PS on RBC surface ), anti-integrin-alpha(v)beta3 , anti-thrombospondin-1 (TSP-1), and PD98059 ( a selective inhibitor of MAPK phosphorylation )
Reyes-Reyes et al., Exp Cell Res 2008 (Adenocarcinoma...) : We have previously shown that P-selectin binding to Colo-320 human colon carcinoma cells induces specific activation of the alpha(5)beta(1) integrin with a concomitant increase of cell adhesion and spreading on fibronectin substrates in a phosphatidylinositol 3-kinase (PI3-K) and p38 MAPK dependent manner