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BTRC — TYR
Text-mined interactions from Literome
Nakajima et al., Arch Dermatol Res 2012
(Hyperpigmentation) :
Real-time RT-PCR and western blotting of Ax-treated HEEs revealed that the
SCF stimulated expression of
tyrosinase (TYR) , TYR related protein-1 (TYRP1), and Pmel17, as well as microphthalmia associated transcription factor ( MITF ), is significantly suppressed by Ax at the transcriptional and translational levels
Wakabayashi et al., J Dermatol Sci 2013
(Lentigo) :
Pre-treatment of cultured normal human melanocytes with the NCMs interrupted the
EDN1+SCF induced stimulation of steady-state levels of MITF at the transcriptional and translational levels and
TYR activity without any direct inhibitory effect on the catalytic activity of TYR in vitro