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CRH — IL2
Text-mined interactions from Literome
Karanth et al., Neuroimmunomodulation 1999
:
Effects of cholinergic agonists and antagonists on
interleukin-2 induced
corticotropin releasing hormone release from the mediobasal hypothalamus ... In previous research we found that
interleukin-2 (IL-2) induced
corticotropin releasing hormone (CRH) release in vitro is mediated by cholinergic activation of nitric oxidergic ( NOergic ) neurons ... To further characterize the mechanism of
IL-2 induced
CRH release, the possible role of nicotinic as well as muscarinic receptors in IL-2 stimulated CRH release was evaluated ... Atropine (ATR) ( 10 ( -7 ) M ) blocked CRH release induced by ACH ( 10 ( -7 ) M ) and the release of
CRH induced by
IL-2 ... The lower concentration of HEX blocked the stimulatory
effect of ACH ( 10 ( -7 ) M ) and
IL-2 on
CRH release ... Furthermore, combined blockade completely blocked the release of
CRH induced by
IL-2 ... We conclude that nicotinic as well as muscarinic receptors play an important role in CRH release, and that they both act to mediate
IL-2 stimulated
CRH release
Bellinger et al., J Neuroimmunol 2001
:
Effects of
interleukin-2 on the expression of
corticotropin releasing hormone in nerves and lymphoid cells in secondary lymphoid organs from the Fischer 344 rat ... These findings indicate that
IL-2 stimulates the synthesis of CRH in nerves that innervate the F344 rat spleen, and
promote the appearance of
CRH ( + ) immunocytes into draining mesenteric lymph nodes
Cambronero et al., Regul Pept 1992
:
Adrenalectomy does not change
CRF secretion
induced by
interleukin-1 from rat perifused hypothalami
Maes et al., Neuro Endocrinol Lett 2003
:
In one study, CRH significantly decreases IFNgamma production by cultured human peripheral blood immunocytes, whereas in other studies
CRH increases the production of cytokines, such as IL-1,
IL-2 and IL-6
Cambronero et al., Endocrinology 1992
:
The present work shows that
interleukin-2 (IL-2) is able to
increase in a dose dependent manner ( 25-100 U/ml )
CRF release from continuous perifused hypothalami ... The
effects of
IL-2 and IL-1 on
CRF secretion are potentiated by the simultaneous action of the two cytokines at the hypothalamus ... The stimulatory
effect of
IL-2 on
CRF secretion is significantly inhibited by the presence of dexamethasone in the perifusion medium ... However, the
CRF response to
IL-2 was similar in adrenalectomized animals and sham operated rats ... The mechanism underlying the
effect of
IL-2 on
CRF release is unknown, but arachidonic acid metabolites do not seem to be involved, since neither a lipooxygenase ( nordihidrogueretic acid ) nor a cyclooxigenase ( indomethacin ) inhibitor affected the hypothalamic secretory response to IL-2
Krause et al., Horm Metab Res 2007
:
alpha-Helical-CRF, a CRH antagonistic peptide, annulled the
CRH effect on SZ95 sebocyte proliferation and
interleukin secretion, while the non-peptidic CRH-R1 selective antagonist antalarmin inhibited the increased production of neutral lipids caused by CRH
Navarra et al., Endocrinology 1991
:
Neither
IL-2 ( 1-10000 U/ml ), IL-8 ( 0.1-10 nM ), tumor necrosis factor ( 10-1000 U/ml ), interferon-alpha 2 ( 10-1000 U/ml ) nor interferon-gamma ( 10-1000 U/ml )
had any effect on hypothalamic
CRH-41 release or pituitary ACTH release
Kageyama et al., J Endocrinol 2009
:
Among them,
interleukin (IL)-6 plays a role in the regulation of
CRF
Raber et al., J Neurosci 1994
:
A stimulatory
effect of
IL-2 on hypothalamic
CRF release and plasma ACTH has already been reported
Sandi et al., Eur J Pharmacol 1995
:
This study investigated the possibility that nitric oxide ( NO ) acts as a mediator of
interleukin-1 induced
CRF release ... The concurrent treatment with NG-nitro-L-arginine and indomethacin ( 14 microM ) -- an inhibitor of prostaglandin production -- reduced
interleukin-1 induced
CRF release to the same level as NG-nitro-L-arginine alone, suggesting that prostaglandins might interact with NO on this interleukin-1 effect
Raber et al., J Pharmacol Exp Ther 1995
:
Interleukin-2 (IL-2) induces
corticotropin releasing factor (CRF) release from the amygdala and involves a nitric oxide mediated signaling ; comparison with the hypothalamic response ... In the present study, we compared the
effects of
IL-2 , acetylcholine and norepinephrine on the in vitro release of
CRF from the amygdala or hypothalamus ...
IL-2 stimulates
CRF release in both regions, in a calcium- and dose dependent manner ... This
IL-2 induced
CRF release is antagonized by Ng-methyl-L-arginine and hemoglobin, known NO antagonists
Schulte et al., Eur J Clin Invest 1994
(Acute Disease...) :
Systemic interleukin-1 alpha and
interleukin-2 secretion in
response to acute stress and to
corticotropin releasing hormone in humans
Hillhouse et al., Brain Res 1994
:
Interleukin-2 stimulates the secretion of arginine vasopressin but not
corticotropin releasing hormone from rat hypothalamic cells in vitro ...
IL-2 did not
increase the secretion of
CRH in either preparation, nor did it prime the cells to respond to a subsequent dose of IL-2
Kakucska et al., Endocrinology 1993
:
Endotoxin induced
corticotropin releasing hormone gene expression in the hypothalamic paraventricular nucleus is
mediated centrally by
interleukin-1
Karanth et al., Proc Natl Acad Sci U S A 1993
:
Stimulation of
corticotropin releasing factor (CRF) release from the hypothalamus by
interleukin 2 (IL-2) was recently demonstrated ... The effects of L-arginine, the substrate for NOS, and NG-monomethyl-L-arginine ( NMMA ), a competitive inhibitor of NOS, on
IL-2 induced
CRF release were studied using mediobasal hypothalami ( MBHs ) incubated in vitro in Krebs-Ringer bicarbonate buffer ... L-Arginine did not alter basal and
IL-2 induced
CRF release after 30 min of incubation but significantly elevated both basal and IL-2 induced CRF release when MBHs were incubated 30 min longer, presumably because the endogenous substrate had been depleted after the initial 30-min incubation period
Karanth et al., Neuroimmunomodulation 1994
:
Cyclosporin A inhibits
interleukin-2 induced release of
corticotropin releasing hormone ... We hypothesized that cyclosporin might therefore inhibit
IL-2 induced acute
CRH release by blocking the dephosphorylation of NOS by calcineurin ... CSA at 10 ( -6 ) or 10 ( -8 ) M did not alter basal release of CRH ; however, addition of either concentration completely blocked the
IL-2 induced release of
CRH
Karanth et al., Neuroimmunomodulation 1995
:
Effects of luteinizing-hormone releasing hormone, alpha-melanocyte stimulating hormone, naloxone, dexamethasone and indomethacin on
interleukin-2 induced
corticotropin releasing factor release ... In the present experiments, we evaluated the
effect of
IL-2 on the release of
corticotropin releasing factor (CRF) from medial basal hypothalami ( MBHs ) incubated in vitro and studied the effect of other agents, whose release is altered in stress, on CRF release ...
IL-2 significantly
stimulated CRF release at concentrations of 10 ( -13 ) and 10 ( -14 ) M, whereas increasing the concentration to 10 ( -12 ) to 10 ( -10 ) M did not produce significant release of CRF ... Although LHRH failed to alter basal CRF release, except for a slight decrease at 10 ( -7 ) M, it completely blocked
IL-2 induced
CRF release at this concentration ... At concentrations of 5 x 10 ( -6 ) and 10 ( -5 ) M, it produced a marked increase in CRF release ; however, the simultaneous exposure of MBHs to each of these concentrations of NAL plus IL-2 caused a dose dependent decrease in
IL-2 induced
CRF release, suggesting that beta-endorphin or other opioid peptides may play a role in IL-2 induced CRF release ... As has been previously shown for IL-1 and IL-6,
IL-2 induced
CRF release was blocked by alpha-melanocyte stimulating hormone ( alpha-MSH ), which at high concentrations also reduced basal CRF release ... The inhibitor of cyclooxygenase, indomethacin ( IND ), also blocked
IL-2 induced
CRF release just as it has previously been shown to block IL-1- and IL-6 induced CRF release
Raber et al., Neurochem Int 1997
:
TGF-beta 1 had no effect on basal release of CRF, nor on the
CRF-release induced by
IL-2 , but selectively blocked the acetylcholine induced release in both amygdala and hypothalamus
Dudley et al., Am J Obstet Gynecol 1999
(Obstetric Labor, Premature...) :
The cytokine
interleukin 1
stimulates production of
corticotropin releasing hormone , and corticotropin releasing hormone in turn regulates cytokine production by immune effector cells