Gene interactions and pathways from curated databases and text-mining

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IL2 — LAT

Text-mined interactions from Literome

Kim et al., Biochem Biophys Res Commun 2009 : Hph-1-ZAP-70-Y319F inhibited the phosphorylation of ZAP-70-Tyr319, LAT-Tyr191 , and p44/42 MAPK induced by TcR stimulation, NFAT- and AP-1 mediated gene transcription, and the induction of CD69 expression and IL-2 secretion
Börner et al., J Biol Chem 2009 (Multiple Sclerosis) : In this way the cannabinoids inhibited the T cell receptor triggered signaling, i.e. the activation of the zeta-chain associated protein kinase of 70 kDa, the linker for activation of T cells , MAPK, the induction of interleukin-2 , and T cell proliferation
Chuck et al., J Immunol 2010 (Lymphoproliferative Disorders) : Analysis of LATY136F T cells indicated that the interaction between LAT and PLC-gamma1 plays an important role in TCR mediated signaling, proliferation, and IL-2 production