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PDK1 — PI3

Text-mined interactions from Literome

Chen et al., Biochemistry 2001 : Thus, the insulin stimulated increase in PDK-1 catalytic activity may involve PI 3-kinase- and phosphorylation dependent mechanisms
Choi et al., Mol Cells 2005 (MAP Kinase Signaling System) : PDK-1 activates PI3-kinase/Akt signaling and regulates fundamental cellular functions, such as growth and survival
Slagsvold et al., EMBO J 2006 : Here, we provide evidence that the cytokine independent survival kinase CISK is activated downstream of the PI 3-kinase dependent kinase PDK1 on endosomes and negatively regulates the lysosomal degradation of CXCR4
Shibata et al., Biochem Pharmacol 2008 (Neovascularization, Pathologic) : Western blot analysis revealed that the anti-angiogenic effect of delta-T3 is attributable to regulation of growth factor dependent phosphatidylinositol-3 kinase (PI3K)/phosphoinositide dependent protein kinase ( PDK ) /Akt signaling as well as to induction stress response in endothelial cells
Reyes-Gordillo et al., Am J Pathol 2011 (Liver Cirrhosis) : The lack of AKT phosphorylation was not due to the inhibition of PDGF-ßr phosphorylation, the activation of phosphoinositide 3-kinase (PI3K) , pyruvate dehydrogenase kinase isozyme 1 ( PDK1 ), and mammalian target of rapamycin (mTOR)