Sanchez et al., J Rheumatol 2002
(Cadaver...) :
They fully blocked PGE2 production, inhibited IL-6 synthesis, and increased aggrecan synthesis
Law et al., Arthritis Res Ther 2012
(Arthritis, Rheumatoid) :
Patients with early RA were more likely to produce IL-6 in response to no epitope or to citrullinated aggrecan , while patients with longstanding RA were more likely to produce IL-6 to more than one epitope