Gene interactions and pathways from curated databases and text-mining

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CREB1 — OPN1LW

Text-mined interactions from Literome

Adamson et al., J Virol 1999 : However, mutational analysis indicates that Z inhibition of CREB activity requires the direct interaction between Z and CBP but not the direct interaction between Z and CREB
Shenkar et al., Am J Physiol Lung Cell Mol Physiol 2001 (Endotoxemia...) : Inhibition of xanthine oxidase before hemorrhage, but not before endotoxemia, decreased p65-CBP interactions while increasing those between CREB and CBP
Lu et al., J Biol Chem 2003 : Here we investigate the role of CBP acetylase activity in CREB mediated gene expression
Shi et al., Proc Natl Acad Sci U S A 2004 : A CREB mutant containing Ala substitutions at ATM phosphorylation sites displayed enhanced transactivation potential, resistance to inhibition by IR, and increased binding to CBP
Constantinescu et al., J Biol Chem 2004 (MAP Kinase Signaling System) : Under these conditions p90RSK is no longer bound to CBP, thereby promoting CBP dependent CREB mediated gene expression
Tullai et al., J Biol Chem 2007 : Binding sites predicted in 6 genes were confirmed by CREB chromatin immunoprecipitation and forskolin induction of CBP binding
Manna et al., J Mol Endocrinol 2007 : Ectopic expression of CBP eliminated the repression of the StAR gene by E1A and potentiated the activity of CREB and cFos/cJun on StAR promoter responsiveness
Geiger et al., Mol Cell Biol 2008 : These data reveal that phosphorylation of CREB is not sufficient for CBP/p300 recruitment and transcriptional activation
Yun et al., Mol Endocrinol 2012 : OT also increased cAMP response element binding ( CREB)/CREB binding protein ( CBP ) expression in the nucleus and induced the formation of CREB1/NF-?B/CBP complexes, which was blocked by the NF-?B-specific small interfering RNA, NF-?B inhibitors, SN50, and bay11-7082
Webster et al., J Biol Chem 2013 : TNF, acting via NF-?B, did not change the levels of CREB , Sp1, or Egr-1 binding to the Ga ( s ) promoter, but it induced a significant reduction in the level of CBP
Masson et al., Nucleic Acids Res 1993 : We discuss the potential roles of ATF1 and CBP100 in regulating CREB activity during differentiation of F9 embryonal carcinoma cells
Kwok et al., Nature 1994 : Consistent with its role as a coactivator, CBP augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes
Montminy et al., Metabolism 1996 : CBP does not regulate the DNA binding, dimerization, or nuclear targeting properties of CREB , but binds selectively to the kinase-inducible 60 amino acid trans-activation domain ( KID ) of CREB, critical for PK-A-inducible transcription
Nakajima et al., Genes Dev 1997 : The adenovirus E1A oncoprotein was found to inhibit phospho ( Ser-133 ) CREB activity by binding to CBP and specifically blocking recruitment of RNA Pol II to the promoter
Goldman et al., Recent Prog Horm Res 1997 (Second Messenger Systems) : This phosphorylation of CREB allows interaction with the co-activator CBP , which binds to components of the basal transcriptional machinery