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RELA — TRPC1
Text-mined interactions from Literome
Marasa et al., Biochem J 2006
:
The expression of
TRPC1 induced by stable transfection of IEC-6 cells with the wild-type TRPC1 gene ( IEC-TRPC1 cells ) increased Ca2+ influx after Ca2+ store depletion and
repressed NF-kappaB transactivation, which was associated with an increase in susceptibility to apoptosis induced by exposure to TNFalpha ( tumour necrosis factor-alpha ) plus CHX ( cycloheximide ) ( TNF-alpha/CHX ), or STS ( staurosporine ) ... Furthermore, inhibition of
TRPC1 expression by transfection with siRNA ( small interfering RNA ) targeting TRPC1 ( siTRPC1 ) decreased Ca2+ influx,
increased NF-kappaB transactivation, and prevented the increased susceptibility of IEC-TRPC1 cells to apoptosis
Takahashi et al., Atherosclerosis 2007
(Hypertrophy) :
In conclusion, our data suggest that Ang II and subsequent
NF-kappaB activation
induces hCASMC hypertrophy through an enhancement of
TRPC1 expression
Marasa et al., Am J Physiol Cell Physiol 2008
:
The present study tests the hypothesis that induced
TRPC1 expression
inhibits NF-kappaB activation by increasing PP2A activity through Ca2+ influx in IECs