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EGFR — GPR62
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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Gene Ontology Complexes receptor complex:
receptor complex complex (PTH1R-TAOK2-VLDLR-TGFBR2-GABRG1-KCTD8-EGFR-RET-NTRK1-RIPK1-INSR-TRPC1-INSRR-GABRA5-FLT4-ADCYAP1R1-GPR37-P2RX2-LOXL4-IMPG2-PKD1L3-NOTCH1-ADRA2A-TRADD-LRP2-MTTP-GPR101-ITLN1-VIPR1-CD200R1-GRM7-GPR84-FCRL5-RNMT-ITGB1-NPR1-SLITRK5-IL4R-KCTD12-PLA2R1-RAMP1-RXRA-RAMP2-PIGR-GPR62-GPR63-GPR61-ITPR3-GPR20-MTNR1A-ROR1-ABCG5-CR2-GPR37L1-LRP1-LRP6-KCTD16-LRP5-CR1L-NTRK2-APP-GABRQ-CSF1-ABCG8-ADRB2-ADRB3-TLR7-GPR119-TAS1R2)
Roka et al., Mol Pharmacol 1999, Small et al., J Biol Chem 2000, Graf et al., J Biol Chem 2003, Breit et al., J Biol Chem 2004, Bomberger et al., J Biol Chem 2005, Turunen et al., Nucleic Acids Res 2007, Ding et al., J Cell Biol 2008, Ghai et al., Proc Natl Acad Sci U S A 2013, Lin et al., J Biol Chem 1995, Hsu et al., Immunity 1996, Zhang et al., Nature 1996
Text-mined interactions from Literome
Santiskulvong et al., Exp Cell Res 2003
:
Matrix metalloproteinases ( MMPs ) have been implicated in the transactivation of the
epidermal growth factor receptor (EGFR) induced by
G-protein coupled receptor ( GPCR ) agonists
Mifune et al., J Biol Chem 2005
:
A
G protein coupled receptor agonist, angiotensin II ( AngII ),
induces epidermal growth factor (EGF) receptor ( EGFR ) transactivation possibly through metalloprotease dependent, heparin binding EGF (HB-EGF) shedding
Yahata et al., J Biol Chem 2006
:
It has been reported that
G protein coupled receptor ( GPCR ) activation
induces epidermal growth factor (EGF) receptor ( EGFR ) transactivation through the shedding of heparin binding EGF-like growth factor ( HB-EGF )
Fischer et al., Methods Mol Biol 2006
:
In this signaling process
G protein coupled receptor ( GPCR ) stimulation
induces phosphorylation of the
EGFR , combining the broad diversity of GPCRs with the potent signaling capacities of this receptor tyrosine kinase
Yin et al., Invest Ophthalmol Vis Sci 2009
:
ERK1/2 mediate wounding- and
G-protein coupled receptor ligands
induced EGFR activation via regulating ADAM17 and HB-EGF shedding
Quinn et al., Mol Endocrinol 2009
(Breast Neoplasms) :
Coordinate regulation of estrogen mediated fibronectin matrix assembly and
epidermal growth factor receptor transactivation by the
G protein coupled receptor , GPR30
Wang et al., Circ Res 2009
(Carotid Artery Diseases...) :
To understand the
role of
epidermal growth factor receptor (EGFR) transactivation in
G protein coupled receptor ( GPCR ) agonist induced signaling events, we have studied the capacity of thrombin in the activation of Gab1-SHP2 in vascular smooth muscle cells ( VSMCs )
Chun et al., Carcinogenesis 2009
(Papilloma...) :
G protein coupled receptor ( GPCR ) activation of
EGFR has been reported to involve Src 's activation via a GPCR-beta-arrestin-Src complex