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CDK8 — POLR2A
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
Complex of 55 proteins
Sato et al., Mol Cell 2004
-
IRef Bind Interaction:
Complex of 35 proteins
Sato et al., Mol Cell 2004
-
IRef Bind Interaction:
Complex of 58 proteins
Sato et al., Mol Cell 2004
-
IRef Bind Interaction:
Complex of 71 proteins
Sato et al., Mol Cell 2004
-
IRef Bind Interaction:
Complex of 101 proteins
Sato et al., Mol Cell 2004
-
IRef Bind Interaction:
Complex of 62 proteins
Sato et al., Mol Cell 2004
-
IRef Biogrid Interaction:
CDK8
—
POLR2A
(direct interaction, enzymatic study)
Ramanathan et al., J Biol Chem 2001*
-
IRef Biogrid Interaction:
CDK8
—
POLR2A
(direct interaction, enzymatic study)
Pinhero et al., Eur J Biochem 2004*
-
IRef Biogrid Interaction:
CDK8
—
POLR2A
(colocalization, biochemical)
Cho et al., Mol Cell Biol 1998
-
IRef Biogrid Interaction:
CDK8
—
POLR2A
(physical association, affinity chromatography technology)
Cho et al., Mol Cell Biol 1998
-
MIPS CORUM HES1 promoter-Notch enhancer complex:
HES1 promoter-Notch enhancer complex complex (CCNT1-CDK7-CDK8-CDK9-EP300-MAML1-MED1-NOTCH1-POLR2A-RBPJ-INPP5K-SUPT16H-SUPT6H)
Fryer et al., Mol Cell 2004
-
MIPS CORUM RNA polymerase II complex (RPB1, RAP74, CDK8, CYCC, SRB7, BAF190, BAF47), chromatin structure modifying:
RNA polymerase II complex (RPB1, RAP74, CDK8, CYCC, SRB7, BAF190, BAF47), chromatin structure modifying complex (CCNC-CDK8-GTF2F1-MED21-POLR2A-SMARCB1-SMARCA2-SMARCA4)
Cho et al., Mol Cell Biol 1998
-
MIPS CORUM RNA polymerase II complex (CBP, PCAF, RPB1, BAF47, CYCC, CDK8), chromatin structure modifying:
RNA polymerase II complex (CBP, PCAF, RPB1, BAF47, CYCC, CDK8), chromatin structure modifying complex (CCNC-CDK8-CREBBP-KAT2B-POLR2A-SMARCB1)
Cho et al., Mol Cell Biol 1998
-
MIPS CORUM RNA polymerase II complex, chromatin structure modifying:
RNA polymerase II complex, chromatin structure modifying complex (CCNC-CDK8-DRAP1-GTF2B-GTF2E1-GTF2F1-GTF2H1-MED21-PCSK4-POLR2A-SMARCB1-SMARCC1-SMARCC2-TBP-SMARCA2-SMARCA4-SMARCD1-SMARCD2-SMARCD3)
Cho et al., Mol Cell Biol 1998
-
MIPS CORUM RNA polymerase II complex, chromatin structure modifying:
RNA polymerase II complex, chromatin structure modifying complex (CCNC-CDK8-CREBBP-ERCC3-GTF2B-GTF2F1-GTF2H3-MED21-KAT2B-POLR2A-SMARCA2-SMARCA4-SMARCB1)
Cho et al., Mol Cell Biol 1998
-
IRef Corum Interaction:
Complex of CCNC-POLR2A-CDK8-SMARCB1-CREBBP-KAT2B
(association, ion exchange chromatography)
Cho et al., Mol Cell Biol 1998
-
IRef Corum Interaction:
Complex of 14 proteins
(association, chromatin immunoprecipitation assay)
Fryer et al., Mol Cell 2004
-
IRef Corum Interaction:
Complex of 27 proteins
(association, far western blotting)
Cho et al., Mol Cell Biol 1998
-
IRef Corum Interaction:
Complex of SMARCA4-SMARCA2-POLR2A-CCNC-CDK8-GTF2F1-SMARCB1-MED21
(association, far western blotting)
Cho et al., Mol Cell Biol 1998
-
IRef Corum Interaction:
Complex of 20 proteins
(association, affinity chromatography technology)
Cho et al., Mol Cell Biol 1998
-
IRef Hprd Interaction:
CDK8
—
POLR2A
(in vitro)
Rickert et al., Oncogene 1996*, Neish et al., Nucleic Acids Res 1998*
-
IRef Hprd Interaction:
CDK8
—
POLR2A
(in vivo)
Rickert et al., Oncogene 1996*, Neish et al., Nucleic Acids Res 1998*
-
IRef Hprd Interaction:
Complex of 13 proteins
(in vivo)
Crowley et al., Mol Endocrinol 2002*
-
IRef Hprd Interaction:
Complex of 82 proteins
(in vivo)
Cho et al., Mol Cell Biol 1998
-
IRef Intact Interaction:
Complex of MED8-MED12-CDK8-MED10-POLR2A
(association, anti tag coimmunoprecipitation)
Sato et al., Mol Cell 2004
-
IRef Intact Interaction:
Complex of 43 proteins
(association, anti tag coimmunoprecipitation)
Sato et al., Mol Cell 2004
-
IRef Intact Interaction:
Complex of 115 proteins
(association, anti tag coimmunoprecipitation)
Sato et al., Mol Cell 2004
-
IRef Intact Interaction:
Complex of 82 proteins
(association, anti tag coimmunoprecipitation)
Sato et al., Mol Cell 2004
-
IRef Intact Interaction:
Complex of 64 proteins
(association, anti tag coimmunoprecipitation)
Sato et al., Mol Cell 2004
-
IRef Intact Interaction:
Complex of 64 proteins
(association, anti tag coimmunoprecipitation)
Sato et al., Mol Cell 2004
-
IRef Intact Interaction:
Complex of 68 proteins
(association, anti tag coimmunoprecipitation)
Sato et al., Mol Cell 2004
-
IRef Intact Interaction:
Complex of POLR2A-MED8-CDK8-MED12-MED26
(association, anti tag coimmunoprecipitation)
Sato et al., Mol Cell 2004
-
IRef Ophid Interaction:
POLR2A
—
CDK8
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
POLR2A
—
CDK8
(aggregation, confirmational text mining)
Neish et al., Nucleic Acids Res 1998*
Text-mined interactions from Literome
Lee et al., Mol Cell Biol 1999
:
The
Mediator complex of Saccharomyces cerevisiae is
required for both general and regulated transcription of
RNA polymerase II (PolII) and is composed of two stable subcomplexes ( Srb4 and Rgr1 subcomplexes )
Mittler et al., EMBO Rep 2001
:
Novel critical
role of a human
Mediator complex for basal
RNA polymerase II transcription
Sato et al., Mol Cell 2004
:
The
Mediator is a multiprotein transcriptional coactivator that is expressed ubiquitously in eukaryotes from yeast to mammals and is
required for induction of
RNA polymerase II (pol II) transcription by DNA binding transcription factors
Takagi et al., J Biol Chem 2006
:
Taken together, these findings lead to the suggestion that
Mediator is
required for basal
RNA polymerase II transcription in vivo
Radhakrishnan et al., Cancer Res 2006
(Neoplasms...) :
Specifically,
ARC inhibits the phosphorylation of
RNA polymerase II by positive transcription elongation factor-b, leading to a block in transcriptional elongation
Thiaville et al., Nucleic Acids Res 2008
:
It is unclear whether
Mediator complex in yeast is
necessary for all
RNA polymerase II (Pol II) transcription or if it is limited to genes activated by environmental stress
Carey et al., Cold Spring Harbor protocols 2010
:
INTRODUCTION : The
Mediator ( Med ) complex plays a key role in promoter-specific activation of transcription by
RNA polymerase II (Pol II)
Han et al., Mol Cell Biol 1999
:
The multisubunit
Mediator complex of Saccharomyces cerevisiae is
required for most
RNA polymerase II (Pol II) transcription