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LPA — NOS3

Text-mined interactions from Literome

Kou et al., Biochemistry 2002 : In endothelial cells, S1P stimulates the EDG-1 receptor mediated activation of the endothelial isoform of nitric oxide synthase ( eNOS ), but the role of LPA in eNOS regulation is less well understood ... In contrast to the cellular responses elicited by S1P in COS-7 cells, LPA can stimulate the activation of eNOS and Akt independently of EDG-1 receptor transfection ... In BAEC, activation of eNOS by LPA is completely blocked by pertussis toxin, by the intracellular calcium chelator BAPTA ( 1,2-bis ( aminophenoxy ) ethane-N, N,N ', N'-tetraacetic acid ), and by the phosphoinositide 3-kinase (PI3-K) inhibitor wortmannin, but is unaffected by U0126, an inhibitor of mitogen activated protein ( MAP ) kinase pathways ... Taken together, these results indicate that LPA potently activates eNOS in BAEC in a pathway distinct from the EDG-1 receptor, but mediated by a similar receptor mediated pathway dependent on pertussis toxin-sensitive G proteins and involving activation of the PI3-K/Akt pathway ... These studies have identified a role for the phospholipid LPA in eNOS activation, and point out the complementary role of distinct platelet derived lipids in endothelial signaling pathways
Chen et al., Atherosclerosis 2012 (Atherosclerosis) : In HCAECs, LPA reduced eNOS mRNA, phospho-eNOS and total eNOS protein levels
Costa et al., Stem cell research 2013 : We have demonstrated a hitherto unrecognized role for LPA and PAF in the regulation of eNOS subcellular localization