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CSF3 — PTGS2

Text-mined interactions from Literome

Stanford et al., Br J Pharmacol 2000 : Moreover, the differential regulation of GM-CSF and G-CSF release by COX-2 was mimicked by the prostacyclin ( PGI ( 2 ) ) mimetic, cicaprost
Nakata et al., Cancer Sci 2003 (Disease Progression...) : It is known that increased COX-2 activity promotes tumor growth and induces G-CSF and GM-CSF expression in non-malignant cells, and that selective COX-2 inhibitors inhibit the growth of some types of malignant cells ... Therefore, we hypothesized that inhibition of COX-2 activity might suppress constitutive production of G-CSF or GM-CSF in addition to reducing the growth of malignant cells ... We confirmed that the selective COX-2 inhibitor, NS-398 suppressed the constitutive production of G-CSF and GM-CSF, and the cell growth in both OKa-C-1 and MI-4 cell lines