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PTGS2 — RAF1
Text-mined interactions from Literome
Wadleigh et al., J Biol Chem 2000
:
In contrast, endotoxin induced
COX-2 reporter activity is not
blocked by overexpression of dominant negative forms of
Raf-1 , ERK1, or ERK2
Teh et al., J Cell Biochem 2004
(Breast Neoplasms...) :
bFGF regulation of survivin expression was found to be ERK1/2 kinase dependent and bFGF induced phosphorylation of
c-raf was
prevented by the
COX-2 inhibitor
Chang et al., Cell Signal 2005
:
PMA induced
COX-2 expression was
attenuated by PKC inhibitors ( Go 6976 and Ro 31-8220 ), a Ras inhibitor ( manumycin A ), a
Raf-1 inhibitor ( GW 5074 ), a MEK inhibitor ( PD 098059 ), and an NF-kappaB inhibitor ( PDTC ), but not by a tyrosine kinase inhibitor ( genistein ) or a p38 MAPK inhibitor ( SB 203580 )
Gwak et al., J Cancer Res Clin Oncol 2006
:
LPC induced
Raf-1 activation was
responsible for this
COX-2 induction
Chang et al., Pharmacol Res 2009
:
In this study, we further investigated the
role of
Raf-1 in YC-1 induced nuclear factor-kappaB (NF-kappaB) activation and
COX-2 expression in A549 cells ... YC-1 induced
COX-2 expression was
attenuated by a
Raf-1 inhibitor ( GW 5074 ) in a concentration dependent manner
Kim et al., Biochem Pharmacol 2010
:
We conclude that MKK4, MEK1, and
Raf-1 are
targets of cyanidin for the suppression of UVB induced
COX-2 expression