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FOS — SP1

Pathways - manually collected, often from reviews:

• BioCarta keratinocyte differentiation: c/EBP-alpha (CEBPA) → SP1/c-FOS/c-JUN/ETS/c/EBP-alpha complex (SP1-FOS-JUN-ETS2_ETS1-CEBPA) (modification, collaborate)
  
• BioCarta keratinocyte differentiation: SP1 → SP1/c-FOS/c-JUN/ETS/c/EBP-alpha complex (SP1-FOS-JUN-ETS2_ETS1-CEBPA) (modification, collaborate)
  
• BioCarta keratinocyte differentiation: SP1 → AP-1 complex (FOS-JUN) (modification, collaborate)
• BioCarta keratinocyte differentiation: HOXA7 → SP1/c-FOS/c-JUN/ETS/c/EBP-alpha complex (SP1-FOS-JUN-ETS2_ETS1-CEBPA) (modification, inhibits)
  
• BioCarta keratinocyte differentiation: SP1/c-FOS/c-JUN/ETS/c/EBP-alpha complex (SP1-FOS-JUN-ETS2_ETS1-CEBPA) → AP-1 complex (FOS-JUN) (modification, collaborate)
• BioCarta keratinocyte differentiation: SP1/c-FOS/c-JUN/ETS/c/EBP-alpha complex (SP1-FOS-JUN-ETS2_ETS1-CEBPA) → ETS (ETS2/ETS1) (modification, collaborate)
• BioCarta keratinocyte differentiation: SP1 → AP-1 complex (FOS-JUN) (modification, collaborate)
• FastForward regulation: SP1 → FOS (transcriptional regulation, unknown)
  Evidence: DNABINDING, PROMACTIVITY
• FastForward regulation: SP1 → FOS (transcriptional regulation, unknown) Duan et al., Mol Endocrinol 1999*, Duan et al., Endocrinology 1998*
  Evidence: DNABINDING, PROMACTIVITY
• FastForward regulation: SP1 → FOS (transcriptional regulation, increase) Udvadia et al., Proc Natl Acad Sci U S A 1993*
  Evidence: DNABINDING, PROMACTIVITY
• NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: AP1 complex (FOS-JUN) → SMAD2-3/SMAD4/SP1 complex (SMAD2_SMAD3-SMAD4-SP1) (transcription, activates)
  Brodin et al., J Biol Chem 2000
  Evidence: mutant phenotype, reporter gene, physical interaction, other species
• NCI Pathway Database AP-1 transcription factor network: JUN/JUN-FOS complex (JUN-FOS_JUN) → SP1 (SP1) (transcription, activates) Scholer et al., Science 1986*, Lee et al., Nature 1987*, Lee et al., Cell 1987*, Haslinger et al., Proc Natl Acad Sci U S A 1985*
  Evidence: reporter gene, physical interaction
• NCI Pathway Database FOXA1 transcription factor network: AP1 complex (FOS-JUN) → SP1 (SP1) (transcription, activates) Eeckhoute et al., Genes Dev 2006
  Evidence: mutant phenotype, reporter gene, physical interaction
• WikiPathways Oxidative Stress: FOS/JUNB → NFKB1/SP1/NFE2L2 (activation)

Text-mined interactions from Literome

Chen et al., Biochem Biophys Res Commun 1999 : Furthermore, the specific role of Sp1 in c-Fos response was confirmed by using the reporter plasmid driven by SV40 early promoter
García-Lora et al., Cancer Immunol Immunother 2001 : Here we report that PSK enhanced AP-1 and CRE binding activities, whereas IL-2 increased AP-1 and SP-1 and modified GAS/ISRE, IRF-1 and STAT5
Chen et al., Blood 2004 : Overexpression of Sp1 enhanced MEKK-1 induced MRE promoter activity and a dominant negative c-Fos blocked this Sp1 response