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APC — TNF

Text-mined interactions from Literome

Oka et al., Infect Immun 2000 (Gastritis...) : APC inhibited the secretion of tumor necrosis factor alpha (TNF-alpha) induced by H. pylori LPS
White et al., Br J Haematol 2000 (Translocation, Genetic) : We assessed the effect of APC on LPS induced tumour necrosis factor alpha (TNF-alpha) production and on the activation of the central proinflammatory transcription factor nuclear factor-kappaB (NF-kappaB) in a THP-1 cell line ... APC inhibited LPS induced production of TNF-alpha both in the presence and absence of fetal calf serum ( FCS ), although the effect was less marked with 10 % FCS
Schmidt-Supprian et al., Eur Cytokine Netw 2000 (Inflammation) : We report that APC inhibits in vitro the release of tumor necrosis factor (TNF) and macrophage migration inhibitory factor ( MIF ), two known cytokine mediators of bacterial septic shock, from lipopolysaccharide (LPS) stimulated human monocytes
Bertho et al., Hum Immunol 2001 (Burkitt Lymphoma...) : In antigen presenting cells (APC) , TNFalpha increased antigen presentation, notably by up-regulation of HLA class II expression
Esmon et al., Crit Care Med 2001 (Disease Models, Animal...) : In vitro experiments have shown that APC can inhibit neutrophil binding to selectins : Endothelial cell protein C receptor, a protein C/APC binding receptor, can bind to proteinase 3 bound to Mac-1 on leukocytes, potentially blocking tight leukocyte adhesion ; and APC can inhibit tumor necrosis factor-alpha secretion by monocytes and other cell lines by interfering with nuclear factor-kappaB nuclear translocation
Okajima et al., Immunol Rev 2001 (Inflammation) : APC directly inhibits the production of TNF-alpha by inhibiting the activation of both nudear factor kappaB (NFkappaB) and activator protein-1 in monocytes stimulated with LPS
Yuksel et al., Thromb Haemost 2002 (MAP Kinase Signaling System...) : Activated protein C (APC) , an important natural anticoagulant, inhibits tumor necrosis factor-alpha (TNF-alpha) production and attenuates various deleterious events induced by lipopolysaccharide (LPS), contributing thereby to a significant reduction of mortality in patients with severe sepsis ... In this study, we investigated the mechanism ( s ) by which APC inhibits TNF-alpha production by LPS stimulated human monocytes in vitro ... Although APC inhibited LPS induced TNF-alpha production in a concentration dependent fashion, diisopropyl fluorophosphate treated APC, an active-site blocked APC, had no effect ... These observations strongly suggest that APC inhibited LPS induced TNF-alpha production by inhibiting the activation of both NF-kappa B and AP-1 and that the inhibitory activity of APC might depend on its serine protease activity
Isobe et al., Journal of thrombosis and haemostasis : JTH 2004 (Stomach Ulcer) : Furthermore, APC inhibited WIRS induced increases in plasma levels of TNF-alpha
Okajima et al., Clin Chem Lab Med 2004 (Inflammation) : APC inhibited ET-induced TNF-alpha production in human monocytes by inhibiting activation of nuclear factor K-B and activator protein-1 in vitro
Okajima et al., Curr Vasc Pharmacol 2004 (Hypotension...) : APC inhibits ET-induced TNF-alpha production in vitro in human monocytes by inhibiting activation of NFkappaB and AP-1 by inhibiting degradation of IkappaB and mitogen activated protein kinase pathways, respectively
Yamaguchi et al., Scand J Gastroenterol 2006 (Liver Failure, Acute) : The effect of APC on the expression of tumor necrosis factor (TNF)-alpha and monocyte chemoattractant protein (MCP)-1 from LI90 stellate cells was also evaluated ... APC significantly inhibited in vitro the expression of TNFalpha and MCP-1 from LI90 stellate cells
Xue et al., Arthritis Rheum 2007 (Arthritis, Rheumatoid...) : Furthermore, APC directly suppressed the production of tumor necrosis factor (TNF) and the activation of NF-kappaB and MAP kinase p38, and inhibitors of NF-kappaB or p38 reduced the production of MMP-9, suggesting that APC inhibits MMP-9 by blocking TNF, NF-kappaB, and p38
Guitton et al., Am J Physiol Cell Physiol 2011 : Analysis of the regulatory mechanisms mediated by APC on vascular human EC shows that APC impairs TNF signaling by triggering a preemptive activation of intracellular pathways
Murakami et al., Am J Physiol 1997 (Leukopenia) : APC, but not DEGR-Xa or DIP-APC , significantly inhibited the LPS induced increase in the plasma level of TNF ... APC significantly inhibited the production of TNF by LPS stimulated monocytes in a dose dependent fashion in vitro, but DIP-APC did not