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ADM — CALCRL

Pathways - manually collected, often from reviews:

• Reactome Reaction: ADM → CALCRL (reaction) Kamitani et al., FEBS Lett 1999*, Aiyar et al., Mol Cell Biochem 2001*, Wenzel-Seifert et al., Biochem Pharmacol 2002, Zhang et al., Eur J Pharmacol 2003, Roh et al., J Biol Chem 2004*, Lambert et al., Science signaling 2008, Mitsuhashi et al., J Biol Chem 1989, Kozasa et al., Proc Natl Acad Sci U S A 1988, Kitamura et al., Biochem Biophys Res Commun 1993*, McLatchie et al., Nature 1998, Baker et al., J Biol Chem 1998
• Reactome Reaction: ADM → CALCRL (indirect_complex) Kamitani et al., FEBS Lett 1999*, Aiyar et al., Mol Cell Biochem 2001*, Roh et al., J Biol Chem 2004*, Kitamura et al., Biochem Biophys Res Commun 1993*, McLatchie et al., Nature 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: CALCRL — ADM (in vitro) McLatchie et al., Nature 1998
• IRef Hprd Interaction: CALCRL — ADM (in vivo) McLatchie et al., Nature 1998

Text-mined interactions from Literome

Kamitani et al., FEBS Lett 1999 : We also found that adrenomedullin increased cAMP levels in HeLa EBNA and 293 EBNA cells, expressing both the receptor activity modifying protein 2 and calcitonin receptor-like receptor proteins
Hjelmqvist et al., Am J Physiol 1997 : Vasodilation and glomerular binding of adrenomedullin in rabbit kidney are not CGRP receptor mediated