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PDLIM7 — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Calzolari et al., Head Neck 1999
(Epstein-Barr Virus Infections...) :
Our data may suggest that both EBV infection and
LMP-1 expression may
cause p53 loss of function even in the absence of p53 gene mutations, as assessed by SSCP
Liao et al., Zhonghua Zhong Liu Za Zhi 2001
(Nasopharyngeal Neoplasms) :
To ascertain if EBV encoded
latent membrane protein 1 (LMP1) induces
p53 expression via NF-kappa B signaling ...
LMP1 induced
p53 expression via NF-kappa B signaling pathway
Deng et al., Cell Res 2003
(Nasopharyngeal Neoplasms) :
The present study demonstrated that
LMP1 could
induce the accumulation of
p53 protein and upregulate its transactivity in a dose dependent manner, which resulted in the decrease of the kinase activity of cdc2/cyclin B complex and inducing arrest at G2/M phase through the activation of NF-kappaB and AP-1 signaling pathways, and the effect of NF-kappaB was more obvious than that of AP-1
Wu et al., Lab Invest 2004
(Carcinoma, Squamous Cell...) :
Only the
EBV-LMP1 but not the EBV-LMP2A gene could
enhance p53 to upregulated mdm2 expression
Liu et al., Oncogene 2005
:
Regarding the mechanisms of
p53 repression by
LMP1 , we found that LMP1 did not inhibit p53 function through direct interaction, by promoting protein degradation or reducing its DNA binding ability ... Using chimeric proteins in the reporter assay, we demonstrated that
LMP1 inhibited
p53 transactivation by influencing the N-terminal transactivation domain of p53 ... Furthermore, blockage of NF-kappaB signalling by IkappaB-DeltaN was shown to abolish the
repression of
p53 by
LMP1 , suggesting that LMP1 likely repressed p53 function through the NF-kappaB pathway
Li et al., Cancer Lett 2007
(Epstein-Barr Virus Infections...) :
Furthermore,
LMP1 induced phosphorylation of
p53 at Ser15 was directly by ERKs ; at Ser20 and Thr81 by JNK, at Ser 15 and Ser392 by p38 kinase ... These results strongly suggest that MAP kinases have a direct role in
LMP1 induced phosphorylation of
p53 at multiple sites, which provide a novel view for us to understand the mechanism of the activation of p53 in the carcinogenesis of nasopharyngeal carcinoma
Li et al., Cancer Res 2007
(Breast Neoplasms...) :
Similar to that of LAPF silencing, silencing of endogenous
p53 expression in L929 cells could significantly
impair TNF-alpha induced
LMP and apoptosis ... The data suggest that phosphorylated
p53 ( Ser ( 15/18 ) ) might translocate to lysosome via forming complexes with adaptor protein LAPF and subsequently
result in
LMP and apoptosis, which might be in a transcription independent manner
Li et al., FEBS Lett 2008
:
Furthermore, the mechanism of
p53 accumulation
mediated by
LMP1 from post-translational level-phosphorylation and ubiquitination were determined ... Therefore, the
effects of EBV
LMP1 on
p53 may potentially contribute to EBV associated pathogenesis
Forte et al., J Virol 2012
(Epstein-Barr Virus Infections) :
EBV
latent membrane protein 1 (LMP1) was sufficient to induce miR-34a requiring downstream NF-?B activation but
independent of functional
p53