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PLAU — TP53

Text-mined interactions from Literome

Shetty et al., J Biol Chem 2005 (Inflammation) : Single chain uPA also enhanced p53 expression to the same extent as intact two chain active uPA and the amino-terminal fragment ... Pretreatment of cells with anti-beta1 integrin antibody blocked uPA induced p53 expression ... uPA induced p53 expression occurs without increased p53 mRNA expression ... uPA induced p53 expression does not require activation of tyrosine kinases ... Inactivation of protein-tyrosine phosphatase SHP-2 inhibits both basal and uPA induced p53 expression ... Plasmin did not alter uPA mediated p53 expression
Shetty et al., Mol Cell Biol 2007 (Lung Neoplasms) : Inhibition of p53 by RNA silencing in Beas2B human airway epithelial cells conversely increased basal as well as uPA mediated uPAR expression and stabilized uPAR mRNA
Shetty et al., Am J Physiol Lung Cell Mol Physiol 2008 (Acute Lung Injury...) : In addition, uPA mediated signaling controls the expression of the tumor suppressor protein p53 in lung epithelial cells at the posttranslational level
Bhandary et al., Am J Physiol Lung Cell Mol Physiol 2012 (Acute Lung Injury...) : Thus p53 is increased and inhibits expression of uPA and uPAR while increasing PAI-1, changes that promote ATII cell apoptosis in mice with BLM induced ALI ... We show that CSP, an intervention targeting this pathway, protects the lung epithelium from apoptosis and prevents PF in BLM induced lung injury via uPA mediated inhibition of p53 and PAI-1