UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to NGFR

IRAK1 — NGFR

Pathways - manually collected, often from reviews:

KEGG Neurotrophin signaling pathway: NGFR → IRAK1/IRAK2/IRAK3/IRAK4 (protein-protein, binding/association)
NCI Pathway Database p75(NTR)-mediated signaling: NGF (dimer)/TRKA complex (NTRK1-NGF) → NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs complex (NGF-NGFR-TRAF6-RIPK2-IRAK1-SQSTM1-PRKCI_PRKCZ) (modification, inhibits)
Hamanoue et al., Mol Cell Neurosci 1999, Wooten et al., J Biol Chem 2001, Khursigara et al., J Neurosci 2001, Mamidipudi et al., J Biol Chem 2002, Yeiser et al., J Neurosci 2004, Carter et al., Science 1996
Evidence: mutant phenotype, reporter gene, other species
NCI Pathway Database p75(NTR)-mediated signaling: NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs complex (NGF-NGFR-TRAF6-RIPK2-IRAK1-SQSTM1-PRKCI_PRKCZ) → IKK complex complex (CHUK-IKBKB-IKBKG) (modification, activates)
Hamanoue et al., Mol Cell Neurosci 1999, Wooten et al., J Biol Chem 2001, Khursigara et al., J Neurosci 2001, Mamidipudi et al., J Biol Chem 2002, Yeiser et al., J Neurosci 2004, Carter et al., Science 1996
Evidence: mutant phenotype, reporter gene, other species
NCI Pathway Database p75(NTR)-mediated signaling: NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK complex (NGF-NGFR-TRAF6-RIPK2-IRAK1) → Atypical PKCs (PRKCI/PRKCZ) (modification, collaborate)
Wooten et al., J Biol Chem 2001, Mamidipudi et al., J Biol Chem 2002
Evidence: physical interaction, other species
NCI Pathway Database p75(NTR)-mediated signaling: NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK complex (NGF-NGFR-TRAF6-RIPK2-IRAK1) → p62 (SQSTM1) (modification, collaborate) Wooten et al., J Biol Chem 2001, Mamidipudi et al., J Biol Chem 2002
Evidence: physical interaction, other species
NCI Pathway Database p75(NTR)-mediated signaling: NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK complex (NGF-NGFR-TRAF6-RIPK2-IRAK1) → NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs complex (NGF-NGFR-TRAF6-RIPK2-IRAK1-SQSTM1-PRKCI_PRKCZ) (modification, collaborate)
Wooten et al., J Biol Chem 2001, Mamidipudi et al., J Biol Chem 2002
Evidence: physical interaction, other species
NCI Pathway Database p75(NTR)-mediated signaling: Atypical PKCs (PRKCI/PRKCZ) → NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs complex (NGF-NGFR-TRAF6-RIPK2-IRAK1-SQSTM1-PRKCI_PRKCZ) (modification, collaborate)
Wooten et al., J Biol Chem 2001, Mamidipudi et al., J Biol Chem 2002
Evidence: physical interaction, other species
NCI Pathway Database p75(NTR)-mediated signaling: p62 (SQSTM1) → NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs complex (NGF-NGFR-TRAF6-RIPK2-IRAK1-SQSTM1-PRKCI_PRKCZ) (modification, collaborate)
Wooten et al., J Biol Chem 2001, Mamidipudi et al., J Biol Chem 2002
Evidence: physical interaction, other species
NCI Pathway Database p75(NTR)-mediated signaling: MYD88 (MYD88) → NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK complex (NGF-NGFR-TRAF6-RIPK2-IRAK1) (modification, activates)
Mamidipudi et al., J Biol Chem 2002
Evidence: physical interaction, other species
NCI Pathway Database p75(NTR)-mediated signaling: NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK complex (NGF-NGFR-TRAF6-RIPK2-IRAK1) → NGF (dimer)/p75(NTR)/TRAF6/RIP2 complex (NGF-NGFR-TRAF6-RIPK2) (modification, collaborate)
Mamidipudi et al., J Biol Chem 2002
Evidence: physical interaction, other species
NCI Pathway Database p75(NTR)-mediated signaling: NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK complex (NGF-NGFR-TRAF6-RIPK2-IRAK1) → IRAK (IRAK1) (modification, collaborate) Mamidipudi et al., J Biol Chem 2002
Evidence: physical interaction, other species
NCI Pathway Database p75(NTR)-mediated signaling: NGF (dimer)/p75(NTR)/TRAF6/RIP2 complex (NGF-NGFR-TRAF6-RIPK2) → IRAK (IRAK1) (modification, collaborate) Mamidipudi et al., J Biol Chem 2002
Evidence: physical interaction, other species
Reactome Reaction: NGFR → IRAK1 (indirect_complex) Lallena et al., Mol Cell Biol 1999, Sanz et al., EMBO J 2000, Wooten et al., J Biol Chem 2001, Khursigara et al., J Biol Chem 1999
Reactome Reaction: IRAK1 → NGFR (indirect_complex) Yang et al., Biochem Biophys Res Commun 2004 *
Reactome Reaction: NGFR → IRAK1 (reaction) Lallena et al., Mol Cell Biol 1999