Fricker et al., Brain Res Mol Brain Res 2005
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Interestingly, the small G-protein Rap and the transcription factor STAT-3 are also involved since reducing the levels of Rap1 ( using small interfering RNA ) or STAT-3 ( using dominant negative STAT3 ) significantly blocks 5-HT1A-receptor mediated neurite outgrowth
Barcelona et al., Invest Ophthalmol Vis Sci 2011
:
In addition, a ( 2 ) M* induced JAK/STAT pathway activation, determined by STAT3 phosphorylation ( p-STAT3 ), which was also blocked by RAP