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BACE1 — STAT1

Text-mined interactions from Literome

Cho et al., Glia 2007 (Alzheimer Disease...) : IFN-gamma induced BACE1 expression is mediated by activation of JAK2 and ERK1/2 signaling pathways and direct binding of STAT1 to BACE1 promoter in astrocytes
Cho et al., Biochem Biophys Res Commun 2009 : Constitutive JAK2/STAT1 activation regulates endogenous BACE1 expression in neurons ... In the present study, we found that endogenous BACE1 expression was mediated by constitutive JAK2/STAT1 activation in neurons ... Therefore, we propose that constitutive JAK2/STAT1 activation mediates endogenous BACE1 expression in neurons and that inhibition of JAK2/STAT1 signaling abrogates basal levels of BACE1 expression and Abeta generation