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PLAU — STAT1

Text-mined interactions from Literome

Dumler et al., J Biol Chem 1999 : This new uPA induced Stat2-Stat1 heterodimer binds to GAS ( the interferon-gamma activation site ) distinct from the interferon stimulated response element to which the p48 protein containing complexes generally bind
Kunigal et al., Blood 2003 : The VSMC uPA receptor (uPAR) receives the signal and activates the transcription factor Stat1 that, in turn, mediates the antiproliferative effects
Patecki et al., Biochem Biophys Res Commun 2007 : We provide evidence that Tyk2, but not Jak1, mediates uPA induced Stat1 phosphorylation and VSMC growth inhibition and suggest a novel function for Tyk2 as an important modulator of the uPA directed VSMC functional behaviour at the place of injury
Dumler et al., J Biol Chem 1998 : Using an electrophoretic mobility shift assay, we then demonstrated that Stat1 is rapidly activated in response to stimulation with uPA and specifically binds to the DNA regulatory elements GAS ( interferon-gamma activation site ) and ISRE ( interferon stimulated response element )
Dumler et al., Arterioscler Thromb Vasc Biol 1999 : Using electrophoretic mobility shift and supershift assays, we then demonstrated that Stat1 is rapidly activated in endothelial cells in response to uPA and ATF ... The uPA induced , time dependent translocation of Stat1 to cell nuclei was confirmed by confocal microscopy study and immunoblotting of nuclear extracts with an anti-Stat1 antibody