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IFNG — IGF1
Text-mined interactions from Literome
Tu et al., Pediatr Res 1999
:
IGF-I increases
interferon-gamma and IL-6 mRNA expression and protein production in neonatal mononuclear cells
Shalita-Chesner et al., Mol Cell Endocrinol 2001
:
This effect was associated with significant reductions in the levels of IGF-l-R mRNA and protein, and with inhibition of IGF-l-R promoter activity, suggesting that TNF-alpha and
IFN-gamma affect
IGF-l-R gene expression at the transcriptional level
Anwar et al., Circulation 2002
(Arteriosclerosis) :
IL-1beta, IL-6, and
IFN-gamma did not
regulate IGF-1 , IGF-1 receptor (R), or IGF binding proteins ( IGFBPs ) ... IL-1beta, IL-6, and
IFN-gamma did not
regulate IGF-1, IGF-1 receptor (R), or
IGF binding proteins ( IGFBPs )
Bernabei et al., Blood 2003
:
These data indicate that
IGF-1 plays a critical role in the desensitization of
IFN-gamma/STAT-1 signaling in T lymphocytes by delivering a signal for IFN-gamma R2 internalization
Hwa et al., J Biol Chem 2004
:
Transcriptional
regulation of
insulin-like growth factor-I by
interferon-gamma requires STAT-5b
Shalita-Chesner et al., J Pediatr Endocrinol 2004
(Bone Neoplasms...) :
The potential involvement of STAT proteins in transcriptional
regulation of the
IGF-IR gene by
IFN-gamma was addressed by transient coexpression of vectors encoding STAT1 and STAT5b, together with an IGF-IR promoter luciferase reporter, in the osteosarcoma derived cell line Saos-2
Sato et al., Int J Oncol 2006
(Carcinoma, Renal Cell...) :
In KU19-20 cells, cell proliferation and survivin expression were significantly
induced by
IGF-1 , whereas they were inhibited by a novel NF-kappaB inhibitor dehydroxymethyl-epoxyquinomicin ( DHMEQ ) and
IFN-gamma
Jia et al., Am J Physiol Heart Circ Physiol 2007
(Carotid Artery Diseases...) :
Here we assessed the expression of IGF-I receptor (IGF-IR) in atherosclerotic plaques and in plaque VSMCs of asymptomatic and symptomatic patients with carotid stenosis and examined the
effect of IGF-I, IL-12, and
IFN-gamma on the expression of
IGF-IR and IGF binding protein (IGFBP)-3 in plaque VSMCs
Hu et al., Mol Hum Reprod 2008
:
IFN-gamma relatively
increased IGF-1 and -2 secretion
Arkins et al., Mol Endocrinol 1995
:
Interferon-gamma inhibits macrophage
insulin-like growth factor-I synthesis at the transcriptional level
Taniguchi et al., Blood 1997
:
Although some inhibitory cytokines including IFNgamma have been shown to downregulate growth factor receptors, the
effect of
IFNgamma on SCF, EP, and
IGF-I receptors of human erythroid progenitor cells has not been defined