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FXR2 — SCARB1
Text-mined interactions from Literome
Chao et al., Nan Fang Yi Ke Da Xue Xue Bao 2009
:
FXR increases the expression of
SR-BI in human vascular endothelium cells
Chao et al., Atherosclerosis 2010
:
Upregulation of
scavenger receptor class B type I expression by activation of
FXR in hepatocyte ... However, the
role of
FXR in the regulation of
SR-BI expression is not well known ... In the present study, we investigate the
regulation of
SR-BI by
FXR in hepatocyte and the corresponding mechanism ... Reporter assays showed that activation of
FXR significantly
enhanced the
SR-BI promoter activity ... Electrophoretic mobility shift and chromatin immunoprecipitation assays indicated that
FXR induced
SR-BI expression by binding to a novel FXR element ( FXRE ), a directed repeat DNA motif, DR8 ( -703 AGGCCAcgttctagAGCTCA -684 )
Li et al., PloS one 2012
:
FXR induces
SR-BI , however, the underlying molecular mechanism of this induction is not known ... A 16-week high-fat diet ( HFD ) feeding in mice increased hepatic
Sr-bi gene expression in a
FXR dependent manner ... In conclusion, the Sr-bi/SR-BI gene is confirmed as a FXR target gene in both mice and humans, and at least in mice,
induction of
Sr-bi by
FXR is via binding to intronic IR1s