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DDIT4 — TSC1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database mTOR signaling pathway:
REDD1/14-3-3 family complex (DDIT4-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB)
→
TSC1/TSC2/14-3-3 family complex (TSC1-TSC2-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB)
(modification, collaborate)
Brugarolas et al., Genes Dev 2004, DeYoung et al., Genes Dev 2008
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database mTOR signaling pathway:
REDD1/14-3-3 family complex (DDIT4-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB)
→
TSC1/TSC2 complex (TSC1-TSC2)
(modification, collaborate)
Brugarolas et al., Genes Dev 2004, DeYoung et al., Genes Dev 2008
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database mTOR signaling pathway:
TSC1/TSC2/14-3-3 family complex (TSC1-TSC2-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB)
→
REDD1 (DDIT4)
(modification, collaborate)
Brugarolas et al., Genes Dev 2004, DeYoung et al., Genes Dev 2008
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database mTOR signaling pathway:
REDD1 (DDIT4)
→
TSC1/TSC2 complex (TSC1-TSC2)
(modification, collaborate)
Brugarolas et al., Genes Dev 2004, DeYoung et al., Genes Dev 2008
Evidence: mutant phenotype, physical interaction
-
WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway:
DDIT4
→
TSC1/TSC2
(activation)
Text-mined interactions from Literome
Sofer et al., Mol Cell Biol 2005
:
REDD1 likely
acts on the
TSC1/2 complex, as regulation of mTOR substrate phosphorylation by REDD1 requires TSC2 and is blocked by overexpression of the TSC1/2 downstream target Rheb but is not blocked by inhibition of AMPK
Vega-Rubin-de-Celis et al., Biochemistry 2010
:
REDD1 induced-mTORC1 inhibition
requires the
TSC1/TSC2 complex , and REDD1 has been proposed to act by directly binding to and sequestering 14-3-3 proteins away from TSC2 leading to TSC2 dependent inhibition of mTORC1