Ozog et al., Cancer Res 2002
(Glioma) :
Ciliary neurotrophic factor (CNTF) in combination with its soluble receptor ( CNTFRalpha ) increases connexin43 expression and suppresses growth of C6 glioma cells ... Taken together, this study has demonstrated that CNTF in combination with its soluble receptor can increase connexin43 expression, increase gap junctional coupling, and reduce the in vitro proliferation of C6 glioma cells
Ozog et al., Mol Biol Cell 2004
:
In this study, we examined the effect of ciliary neurotrophic factor (CNTF) on connexin43 (Cx43) expression and intercellular coupling in astrocytes ... Although CNTF and CNTFRalpha alone had no effect on Cx43 expression, the heterodimer CNTF-CNTFRalpha significantly increased both Cx43 mRNA and protein levels