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EDN1 — JUN
Pathways - manually collected, often from reviews:
-
BioCarta hypoxia-inducible factor in the cardivascular system:
HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN)
→
Endothelin 1 (EDN1)
(transcription, activates)
-
NCI Pathway Database HIF-1-alpha transcription factor network:
AP1 complex (FOS-JUN)
→
ET1 (EDN1)
(transcription, activates)
Yamashita et al., J Biol Chem 2001
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database AP-1 transcription factor network:
JUN/FOS/GATA2 complex (JUN-FOS-GATA2)
→
ET1 (EDN1)
(transcription, activates)
Lee et al., J Biol Chem 1991*, Kawana et al., Mol Cell Biol 1995*
Evidence: reporter gene, physical interaction
Text-mined interactions from Literome
Vichi et al., J Biol Chem 1999
:
Interestingly, the TM7 mutants fell into two classes ; several exhibited greatly decreased AP-1 activity, relative to wild type ETB, whereas others displayed augmented
endothelin stimulated
AP-1 transcriptional activity relative to wild type ETB
Petkova et al., Int J Parasitol 2001
(Chagas Cardiomyopathy...) :
Mitogen activated protein kinases and the transcription factor
activator-protein-1 regulate the expression of
endothelin-1
Shi-Wen et al., Mol Cell Biol 2006
(Pulmonary Fibrosis) :
Constitutive ALK5 independent
c-Jun N-terminal kinase activation
contributes to
endothelin-1 overexpression in pulmonary fibrosis : evidence of an autocrine endothelin loop operating through the endothelin A and B receptors
Kawana et al., Mol Cell Biol 1995
:
Cooperative interaction of GATA-2 and
AP1 regulates transcription of the
endothelin-1 gene
Kojima et al., J Vet Med Sci 1997
:
In the 5'-upstream region of the EDN1 gene, AP-1 and NF-1 elements were found, suggesting the possibility that the expression of swine
EDN1 gene is
controlled by protooncogene products Fos and
Jun , and TGF-beta
Yamboliev et al., Pulm Pharmacol Ther 1998
:
Endothelin-1 activates MAP kinases and
c-Jun in pulmonary artery smooth muscle