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CASP7 — EPO
Text-mined interactions from Literome
Chong et al., Circulation 2002
:
Subsequently,
EPO inhibited
caspase 8-, caspase 1-, and caspase 3-like activities that were linked to mitochondrial cytochrome c release
Chong et al., J Neurosci Res 2003
:
Subsequently,
EPO inhibits
caspase 8-, caspase 1-, and caspase 3-like activities linked to cytochrome c release through mechanisms that are independent from the MAP kinase systems of p38 and JNK
Abdelrahman et al., Shock 2004
(Disease Models, Animal...) :
In cultured human proximal tubule cells,
EPO concentration-dependently reduced the cell death and
increase in
caspase-3 activity caused by either ATP depletion ( simulated ischemia ) or hydrogen peroxide ( oxidative stress )
Fukuda et al., Cell Death Differ 2004
(Body Weight) :
Irradiation induced progenitor cell death in the developing brain is resistant to
erythropoietin treatment and
caspase inhibition
Sharples et al., J Am Soc Nephrol 2004
(Disease Models, Animal...) :
Specifically,
EPO ( 300 U/kg )
reduced glomerular dysfunction and tubular injury ( biochemical and histologic assessment ) and prevented
caspase-3 , -8, and -9 activation in vivo and reduced apoptotic cell death ...
EPO reduced DNA fragmentation and
prevented caspase-3 activation, with upregulation of Bcl-X ( L ) and XIAP
Sekiguchi et al., Biochem Biophys Res Commun 2005
:
In parallel, exposure to high glucose level induced
caspase-3 activation and
erythropoietin also
prevented it ... PI3 kinase inhibitor, wortmannin or LY294002 eliminated
erythropoietin 's inhibitory
effect on
caspase-3 activity
Lui et al., FEBS Lett 2006
:
Erythropoietin activates
caspase-3 and downregulates CAD during erythroid differentiation in TF-1 cells - a protection mechanism against DNA fragmentation
Lee et al., J Neurochem 2006
(Brain Edema...) :
In addition,
EPO reduced the mRNA level of TNF-alpha, Fas and Fas-L, as well as the activities of
caspase-8 , 9 and 3
Nishiya et al., J Pharmacol Sci 2006
(Disease Models, Animal...) :
Five days after MI,
EPO prevented the increase in activated
caspase 3, matrix metalloproteinase-2, and transcriptional activation of activator protein-1 in non infarcted myocardium
Wu et al., Apoptosis 2007
:
The
effects of
EPO on GSK-3beta and
caspase-3 activities were also blocked by LY294002
Ranchon Cole et al., Exp Eye Res 2007
(Radiation Injuries...) :
In parallel, we tested
Epo protection against oxidative stressors on isolated retinas and its
effect on
caspase-9 activity ...
Epo injected at 30,000U/kg body weight, 4h before exposure to the damaging light, protected retinal function and structure against light damage and
induced an increase in
caspase-9 activity and expression
Bürgers et al., Exp Brain Res 2008
(Hypoxia-Ischemia, Brain...) :
Erythropoietin reduced total
caspase activity by nearly 30 % under all the conditions, whereas caspase 3/7 activity was not affected
Wang et al., Eur J Pharmacol 2008
:
Studies on the apoptotic signaling showed that recombinant human
erythropoietin inhibited the activation of
caspase-3 and upregulated the expression of anti-apoptotic gene, Bcl-XL
Wang et al., Free Radic Biol Med 2009
(Macular Degeneration) :
EPO inhibited
caspase-3-like activity
Wang et al., Nan Fang Yi Ke Da Xue Xue Bao 2010
(Status Epilepticus) :
[
Effect of recombinant human
erythropoietin on hippocampal p-Akt and
caspase-9 expressions in rats with status epilepticus and the mechanism ] ... To observe the
effect of recombinant human
erythropoietin ( rhuEPO ) on p-Akt and
caspase-9 expressions in the hippocampus of rats with status epilepticus ( SE ) and explore the neuroprotective mechanism of rhuEPO
Diaz et al., Biol Reprod 2011
:
CASP3 mRNA was increased ( P < 0.01 ) by EPO ( 3.4-fold ) and by PGF ( 2.7-fold ) but was most dramatically increased by PGF+EPO ( 5.3-fold ), whereas
caspase activity was only
increased by PGF ( 1.5-fold ) or
PGF+EPO ( 2.2-fold )
Ge et al., Neurol Sci 2012
:
Finally, TDZD-8 and
EPO significantly
suppressed the enhanced apoptosis and activity of
caspase 3 induced by 6-OHDA