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JUN — PRKCA
Text-mined interactions from Literome
Chen et al., J Biol Chem 1999
:
Using a specific inhibitor of the Ca ( 2+ ) -dependent PKC isoforms, Gö6976, and CaCo-2 cells stably transfected with antisense PKC-alpha cDNA, demonstrated that
PKC-alpha mediated the
AP-1 activation induced by this secosteroid
Chen et al., J Environ Pathol Toxicol Oncol 2000
(MAP Kinase Signaling System) :
These data demonstrate that PKCdelta, PKCepsilon, and
PKCalpha mediate arsenite
induced AP-1 activation in JB6 cells through different MAP kinase ( Erks, JNKs, and p38 kinases ) pathways
Chisamore et al., Clin Cancer Res 2001
(Breast Neoplasms...) :
Stable transfection of
PKCalpha to the T47D : A18 breast cancer cell line
results in increased basal
activator protein-1 activity, reduced ER function, increased proliferation rate, and hormone independent growth ( Tonetti et al., Br. J. Cancer, 83 : 782-791, 2000 )
Soh et al., J Biol Chem 2003
:
A dominant negative mutant of c-Jun inhibited activation of the cyclin D1 promoter in a concentration dependent manner, providing further evidence that
AP-1 activity is
required for activation of the cyclin D1 promoter by
PKC-alpha and PKC-epsilon
Ding et al., Am J Physiol Lung Cell Mol Physiol 2006
(MAP Kinase Signaling System) :
Furthermore, overexpression of dominant negative mutant (DNM) of
PKCalpha or PKCepsilon markedly
blocked AP-1 activation as well as phosphorylation of ERKs and p38 kinase induced by freshly fractured silica
Liao et al., Neurochem Int 2007
:
The inductive action of manganese was accompanied by generation of oxidative stress,
activation of mitogen activated protein kinases ( MAPKs ), AKT, and
protein kinase C-alpha (PKC-alpha) , and increased NF-kappaB and
AP-1 DNA binding activities
Miraoui et al., Hum Mol Genet 2010
(Acrocephalosyndactylia) :
Investigation of the underlying molecular mechanisms revealed that activated FGFR2 enhances EGFR and PDGFRalpha mRNA expression via activation of
PKCalpha dependent
AP-1 transcriptional activity
Lee et al., J Cell Physiol 2010
(MAP Kinase Signaling System) :
Taken together, these data suggest that in A549 cells, TNF-alpha induces MMP-9 expression via the
TNFR1/TRAF2/PKCalpha dependent
JNK1/2/c-Jun and c-Src/EGFR/PI3K/Akt pathways
Abou-Kandil et al., PloS one 2012
:
However, we found that
PKCalpha and PKCepsilon, in Jurkat cells, and PKCetta and PKCdelta, in H9 cells,
increased the level of phosphorylated
c-Jun that interacted with the Sp1-p53 complex
Gruber et al., Exp Cell Res 1995
(Melanoma) :
These results suggest a hypothesis whereby RA-induced nuclear
PKC alpha might
lead to increased
AP-1 activity and show that RA-induced growth inhibition and differentiation are not always accompanied by an inhibition of AP-1 activity as has been proposed by other investigators
Baier-Bitterlich et al., Mol Cell Biol 1996
:
Importantly, the critical AP-1 enhancer element was differentially modulated by these two distinct PKC isoenzymes, since only PKC-theta but not
PKC-alpha overexpression
resulted in an approximately 2.8-fold increase in
AP-1-collagenase promoter CAT expression in comparison with the vector control