◀ Back to NOTCH1

NOTCH1 — SPEN

Pathways - manually collected, often from reviews:

• NCI Pathway Database Notch-mediated HES/HEY network: SHARP/RBPJ/CtIP/CtBP/LSD1 complex (SPEN-RBPJ-RBBP8-CTBP1-KDM1A) → RBPJ/NICD complex (RBPJ-NOTCH1) (modification, collaborate)
  Oswald et al., EMBO J 2002, Oswald et al., Mol Cell Biol 2005, Wang et al., Nature 2007, Tamura et al., Curr Biol 1995
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Notch-mediated HES/HEY network: SHARP/RBPJ/CtIP/CtBP/LSD1 complex (SPEN-RBPJ-RBBP8-CTBP1-KDM1A) → NICD (NOTCH1) (modification, collaborate) Oswald et al., EMBO J 2002, Oswald et al., Mol Cell Biol 2005, Wang et al., Nature 2007, Tamura et al., Curr Biol 1995
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Notch-mediated HES/HEY network: SHARP (SPEN) → RBPJ/NICD complex (RBPJ-NOTCH1) (modification, collaborate)
  Oswald et al., EMBO J 2002, Oswald et al., Mol Cell Biol 2005, Wang et al., Nature 2007, Tamura et al., Curr Biol 1995
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Notch-mediated HES/HEY network: SHARP (SPEN) → NICD (NOTCH1) (modification, collaborate) Oswald et al., EMBO J 2002, Oswald et al., Mol Cell Biol 2005, Wang et al., Nature 2007, Tamura et al., Curr Biol 1995
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Notch-mediated HES/HEY network: SHARP/RBPJ/CtIP/CtBP/LSD1 complex (SPEN-RBPJ-RBBP8-CTBP1-KDM1A) → RBPJ/NICD complex (RBPJ-NOTCH1) (transcription, inhibits)
  Maier et al., Biochem Biophys Res Commun 2000, Iso et al., Mol Cell Biol 2001, Oswald et al., Mol Cell Biol 2005, Wang et al., Nature 2007
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Notch-mediated HES/HEY network: RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300) → SHARP (SPEN) (modification, collaborate) Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Notch-mediated HES/HEY network: RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300) → SHARP/RBPJ complex (SPEN-RBPJ) (modification, collaborate)
  Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Notch-mediated HES/HEY network: SHARP (SPEN) → NICD (NOTCH1) (modification, collaborate) Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Notch-mediated HES/HEY network: SHARP/RBPJ complex (SPEN-RBPJ) → NICD (NOTCH1) (modification, collaborate) Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Notch signaling pathway: SHARP/RBPJ/CtIP/CtBP/LSD1 complex (SPEN-RBPJ-RBBP8-CTBP1-KDM1A) → RBPJ/NICD complex (RBPJ-NOTCH1) (modification, collaborate)
  Oswald et al., EMBO J 2002, Oswald et al., Mol Cell Biol 2005, Wang et al., Nature 2007, Tamura et al., Curr Biol 1995
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Notch signaling pathway: SHARP/RBPJ/CtIP/CtBP/LSD1 complex (SPEN-RBPJ-RBBP8-CTBP1-KDM1A) → NICD (NOTCH1) (modification, collaborate) Oswald et al., EMBO J 2002, Oswald et al., Mol Cell Biol 2005, Wang et al., Nature 2007, Tamura et al., Curr Biol 1995
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Notch signaling pathway: SHARP (SPEN) → RBPJ/NICD complex (RBPJ-NOTCH1) (modification, collaborate)
  Oswald et al., EMBO J 2002, Oswald et al., Mol Cell Biol 2005, Wang et al., Nature 2007, Tamura et al., Curr Biol 1995
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Notch signaling pathway: SHARP (SPEN) → NICD (NOTCH1) (modification, collaborate) Oswald et al., EMBO J 2002, Oswald et al., Mol Cell Biol 2005, Wang et al., Nature 2007, Tamura et al., Curr Biol 1995
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Notch signaling pathway: SHARP (SPEN) → RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2) (modification, collaborate)
  Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Notch signaling pathway: SHARP (SPEN) → NICD (NOTCH1) (modification, collaborate) Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Notch signaling pathway: SHARP/RBPJ complex (SPEN-RBPJ) → RBPJ/NICD/MAML1-2 complex (RBPJ-NOTCH1-MAML1_MAML2) (modification, collaborate)
  Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Notch signaling pathway: SHARP/RBPJ complex (SPEN-RBPJ) → NICD (NOTCH1) (modification, collaborate) Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Tamura et al., Curr Biol 1995
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Notch-mediated HES/HEY network: SHARP/RBPJ complex (SPEN-RBPJ) → RBPJ/NICD/MAML1-2/p300 complex (NOTCH1-RBPJ-MAML1_MAML2-EP300) (transcription, inhibits)
  Ohtsuka et al., EMBO J 1999, Wu et al., Nat Genet 2000, Oswald et al., Mol Cell Biol 2001, Wu et al., Mol Cell Biol 2002, Oswald et al., EMBO J 2002, Jarriault et al., Nature 1995, Nishimura et al., Genomics 1998
  Evidence: mutant phenotype, reporter gene

Text-mined interactions from Literome

Oswald et al., Mol Cell Biol 2005 : We propose that a corepressor complex containing CtIP/CtBP facilitates RBP-Jkappa/SHARP mediated repression of Notch target genes
Doroquez et al., Mech Dev 2007 : At least in part due to loss of Spen dependent down-regulation of Notch signaling, loss of spen also dampens EGFR signaling as evidenced by reduced activity of MAP kinase ( MAPK )