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SNAI2 — TP53
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Direct p53 effectors:
p53 (tetramer) complex (TP53)
→
SLUG (SNAI2)
(transcription, activates)
Wu et al., Cell 2005
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Direct p53 effectors:
p53 (tetramer) complex (TP53)
→
SLUG (SNAI2)
(transcription, activates)
Nakano et al., Mol Cell 2001, Koutsodontis et al., Biochem J 2005, Shi et al., Mol Cell 2007, Das et al., Cell 2007, Gamper et al., Mol Cell Biol 2008, Jansson et al., Nat Cell Biol 2008
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Direct p53 effectors:
p53 (tetramer) complex (TP53)
→
SLUG (SNAI2)
(transcription, activates)
Nakano et al., Mol Cell 2001, Koutsodontis et al., Biochem J 2005, Wu et al., Cell 2005, Tang et al., Mol Cell 2006, Sykes et al., Mol Cell 2006, Shi et al., Mol Cell 2007, Gamper et al., Mol Cell Biol 2008
Evidence: mutant phenotype, reporter gene, physical interaction
Text-mined interactions from Literome
Zilfou et al., Cell 2005
:
In this issue of Cell, Wu et al. ( 2005 ) show that the transcription factor
SLUG is
induced by
p53 and protects hematopoietic progenitor cells from apoptosis triggered by DNA damage
Wu et al., Cell 2005
:
We show that
Slug is transcriptionally
induced by
p53 upon irradiation and then protects the damaged cell from apoptosis by directly repressing p53 mediated transcription of puma, a key BH3-only antagonist of the antiapoptotic Bcl-2 proteins
Wang et al., Nat Cell Biol 2009
(Carcinoma, Non-Small-Cell Lung...) :
Here we show that wild-type p53 ( wtp53 ) suppresses cancer invasion by inducing Slug degradation, whereas mutant
p53 may
stabilize Slug protein ... In contrast, mutant
p53 inactivates Slug degradation and
leads to
Slug accumulation and increased cancer cell invasiveness