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PAK1 — VAV1
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
PAK1
→
VAV1
(indirect_complex)
Parrini et al., Mol Cell 2002, Zhao et al., Biochem J 2005, Allen et al., Blood 2009, Parrini et al., J Biol Chem 2009, Knaus et al., J Biol Chem 1998, Lu et al., Oncogene 1999
-
Reactome Reaction:
PAK1
→
VAV1
(reaction)
Gatti et al., J Biol Chem 1999, Chong et al., J Biol Chem 2001, Parrini et al., Mol Cell 2002, Zhao et al., Biochem J 2005, Allen et al., Blood 2009, Parrini et al., J Biol Chem 2009, Knaus et al., J Biol Chem 1998, Lu et al., Oncogene 1999
Text-mined interactions from Literome
Mainiero et al., Immunity 2000
(MAP Kinase Signaling System) :
In addition, we identified some of the upstream events accompanying the beta1 integrin mediated p38 MAPK activation, namely, the
activation of the Rac guanine nucleotide exchange factor (GEF) p95
Vav , the small G protein Rac1, and the cytoplasmic kinases
Pak1 and MKK3
Fernandez-Zapico et al., Cancer Cell 2005
(Adenocarcinoma...) :
Mechanistically, the effects of
Vav1 require its GEF activity and the activation of Rac1,
PAK1 , and NF-kappaB and involve cyclin D1 upregulation ... Mechanistically, the effects of
Vav1 require its GEF activity and the activation of Rac1,
PAK1 , and NF-kappaB and involve cyclin D1 upregulation
Wilsbacher et al., Cell communication and signaling : CCS 2006
:
In addition, activation of ERK downstream of Vav1 is dependent on autocrine EGF receptor stimulation while active
Vav1 can
stimulate Rac1 and
PAK activation independent of ligand binding to the EGF receptor