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RHO — S1PR2

Text-mined interactions from Literome

Yamamura et al., Ann N Y Acad Sci 2000 (Melanoma, Experimental) : We found that EDG-5 induced Rho activation followed by enhanced tyrosine phosphorylation of FAK and paxillin, and beta 1-integrin activation leading to overexpression of focal adhesion sites, as well as increment of stress fiber formation, must be the molecular basis of inhibition of haptotactic cell motility by Sph-1-P
Ikeda et al., Gastroenterology 2003 : Antiproliferative property of sphingosine 1-phosphate in rat hepatocytes involves activation of Rho via Edg-5
Sugimoto et al., Mol Cell Biol 2003 : The G protein coupled receptors S1P2/Edg5 and S1P3/Edg3 both mediate sphingosine-1-phosphate ( S1P ) stimulation of Rho , yet S1P2 but not S1P3 mediates downregulation of Rac activation, membrane ruffling, and cell migration in response to chemoattractants ... Specific inhibition of endogenous Galpha12 and Galpha13, but not of Galphaq, by expression of respective C-terminal peptides abolished S1P2 mediated inhibition of Rac, membrane ruffling, and migration, as well as stimulation of Rho and stress fiber formation
Hu et al., Am J Physiol Gastrointest Liver Physiol 2006 (Calcium Signaling) : Silencing of S1P(2) but not S1P(1) receptors suppressed S1P stimulated PLC-beta and Rho kinase activities, implying that both signaling pathways were mediated by S1P(2) receptors
Szczepaniak et al., Am J Physiol Lung Cell Mol Physiol 2010 : S1P2 receptor dependent Rho-kinase activation mediates vasoconstriction in the murine pulmonary circulation induced by sphingosine 1-phosphate