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GRB2 — IRS2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of GRB2-IRS2 → IL4 (increases) Zamorano et al., Cell Res 2001*
  Evidence: association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL4 treatment although both proteins were expressed IL4 induced association of IRS2 with GRB2 in B cell blasts
• KEGG Insulin signaling pathway: IRS1/IRS2/IRS4 → GRB2 (protein-protein, activation)
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: IRS2 (IRS2) → RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1) (modification, activates)
  Hennige et al., Mol Cell Endocrinol 2000, Hayashi et al., Oncogene 2000, Maeda et al., Biochem Biophys Res Commun 2004
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1) → IRS2 (IRS2) (modification, activates) Hennige et al., Mol Cell Endocrinol 2000, Hayashi et al., Oncogene 2000, Maeda et al., Biochem Biophys Res Commun 2004
  Evidence: mutant phenotype, assay, physical interaction
• Reactome Reaction: GRB2 → IRS2 (direct_complex)
• Reactome Reaction: GRB2 → IRS2 (reaction) Skolnik et al., Science 1993, Xu et al., J Biol Chem 1995, Ward et al., J Biol Chem 1996*, Okada et al., J Biol Chem 1996, Takahashi et al., Endocrinology 1997, Kim et al., Endocrinology 1998, Kim et al., J Biol Chem 1998
• Reactome Reaction: GRB2 → IRS2 (indirect_complex) Skolnik et al., Science 1993, Xu et al., J Biol Chem 1995, Ward et al., J Biol Chem 1996*, Okada et al., J Biol Chem 1996, Takahashi et al., Endocrinology 1997, Kim et al., Endocrinology 1998, Kim et al., J Biol Chem 1998
• WikiPathways EPO Receptor Signaling: Complex of GRB2-RAF1-SOS1-IRS2-JAK2-IRS1-RASA1 → MAP2K1 (activation)
• WikiPathways Insulin Signaling: SHC3/IRS1/IRS2/SHC1/IRS4/SHC2/GAB1 → RAC1/GRB2/SOS1/RAC2/RRAD/GRB14/SOS2/RAF1/HRAS/GRB10 (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: IRS2 — GRB2 (direct interaction, unspecified method) Liu et al., Cell communication and signaling : CCS 2012
• IRef Biogrid Interaction: IRS2 — GRB2 (physical association, affinity chromatography technology) Bisson et al., Nat Biotechnol 2011
• IRef Ophid Interaction: IRS2 — GRB2 (aggregation, confirmational text mining) Kim et al., J Biol Chem 1998
• IRef Ophid Interaction: IRS2 — GRB2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Kim et al., Endocrinology 1998 (Neuroblastoma) : Treatment with PI 3-K inhibitors induced an increased association of IRS-2 with Grb2 , probably as a result of the increased IRS-2 tyrosine phosphorylation
Kim et al., J Biol Chem 1998 (Neuroblastoma) : In contrast, IGF-I induces a transient tyrosine phosphorylation of IRS-2 and an association of IRS-2 with Grb2