◀ Back to IRF6
IRF6 — LY96
Text-mined interactions from Literome
Shuto et al., Biochem Biophys Res Commun 2005
:
Membrane anchored CD14 is required for
LPS induced TLR4 endocytosis in
TLR4/MD-2/CD14 overexpressing CHO cells
Viriyakosol et al., Hybridoma (Larchmt) 2006
(Sepsis) :
Eleven MAbs were characterized by enzyme linked immunosorbent assay ( ELISA ) with soluble
TLR4/MD-2 complex (sTLR4/MD-2) and sMD-2, Western blotting against sMD-2 monomer and multimers, and
inhibition of direct
LPS binding to sMD-2
Kim et al., Cell 2007
:
Based on structural analysis and mutagenesis experiments on MD-2 and TLR4, we propose a model of
TLR4-MD-2 dimerization
induced by
LPS
Steeghs et al., Infect Immun 2008
:
The species-specific
activation of the
TLR4/MD-2 complex by LpxL1
LPS may have an impact on the use of LpxL1 LPS as an adjuvant and the use of murine immunization models in human meningococcal vaccine development
Tsukamoto et al., Int Immunol 2010
:
We found that
LPS induced
TLR4/MD-2 dimerization occurred only in membrane associated CD14 (mCD14) expressing cells ... These studies suggest that
LPS induced
TLR4/MD-2 receptor dimerization is not essential for signaling but prompts rapid signaling during innate immune responses
Hsu et al., Cancer Res 2011
(Colorectal Neoplasms...) :
Taken together, the results indicate that
stimulation of the
TLR4/MD2 complex by
LPS activates PI3K/AKT signaling and promotes downstream ß1 integrin function, thereby increasing the adhesiveness and metastatic capacity of CRC cells
Ainge et al., J Med Chem 2011
:
Furthermore, the interruption of the
LPS induced 2 : 2
TLR4/MD-2 signaling complex formation by PIM ( 2 ) represents a previously unidentified mechanism involved in the bioactivity of PIM molecules