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BDNF — NTRK1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Suzuki et al., Biochem Biophys Res Commun 2002
:
Brain derived neurotrophic factor (BDNF) binds to and
activates the TrkB
tyrosine kinase receptor to regulate cell differentiation, survival, and neural plasticity in the nervous system
Baker-Herman et al., Nat Neurosci 2004
(Anoxia) :
We used RNA interference ( RNAi ) to interfere with BDNF expression, and
tyrosine kinase receptor inhibition to
block BDNF signaling
Obata et al., Neuroscience 2004
(Pain...) :
Therefore, we suggest that after inflammation near the cell body, NGF synthesized within the nerve root and DRG
induces BDNF expression through
trkA receptors and intracellular ERK-MAPK
Li et al., Blood 2009
(Cell Transformation, Neoplastic...) :
Activation of
TRKA or TRKB by NGF and
BDNF , respectively, efficiently rescued murine myeloid cells from irradiation induced apoptosis
Sato et al., Cell Mol Neurobiol 2011
:
Interestingly, the GFP labeled neurons grew dendrites and activated the
TrkA/TrkB receptors in
response to NGF, but not
BDNF
Barbacid et al., J Neurobiol 1994
:
Brain derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4) specifically
activate the TrkB
tyrosine kinase receptor
Yamada et al., J Biol Chem 1997
:
BDNF binds to and
activates the
tyrosine kinase receptor , TrkB, initiating intracellular signaling and exerting its effects