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EPHB2 — SPHK2

Text-mined interactions from Literome

Blaukat et al., Biol Chem 2001 : Overexpression of sphingosine kinase did not additionally increase the bradykinin induced ERK/MAP kinase activity, indicating a permissive rather than activating role of sphingosine 1-phosphate in B2 receptor mediated mitogenic signaling
Nava et al., Exp Cell Res 2002 (Adenocarcinoma...) : While both ERK and Akt have been implicated in MCF-7 cell growth, SPHK1 stimulated ERK1/2 but had no effect on Akt
Monick et al., Am J Respir Cell Mol Biol 2004 (Respiratory Syncytial Virus Infections) : S1P activated Akt and ERK within minutes, and inhibition of sphingosine kinase blocked RSV induced ERK and Akt activation, leading to accelerated cell death after viral infection
Radeff-Huang et al., J Biol Chem 2007 (Brain Neoplasms...) : ERK activation was also required for TNF-alpha stimulated DNA synthesis but likewise TNF-alpha induced ERK activation was not blocked by inhibition of SphK
Hait et al., J Biol Chem 2007 : Down-regulation of ERK1 blocked EGF induced phosphorylation of SphK2
Kharel et al., Biochem J 2011 : However, SphK1 inhibition did diminish EGF ( epidermal growth factor ) -driven increases in S1P levels and Akt ( also known as protein kinase B ) /ERK ( extracellular-signal regulated kinase ) phosphorylation