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CAV1 — LRP6
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
LRP6
—
CAV1
(physical association, affinity chromatography technology)
Yamamoto et al., Dev Cell 2006
-
IRef Innatedb Interaction:
CAV1
—
LRP6
(unknown, -)
Yamamoto et al., Dev Cell 2006
-
IRef Intact Interaction:
Complex of CAV1-GSK3B-LRP6-CTNNB1-LRP6-CTNNB1-CAV1-GSK3B
(physical association, anti tag coimmunoprecipitation)
Yamamoto et al., Dev Cell 2006
-
IRef Intact Interaction:
Complex of CAV1-LRP6-CAV1-LRP6-CAV1-LRP6
(colocalization, fluorescence microscopy)
Yamamoto et al., Dev Cell 2006
-
IRef Intact Interaction:
CAV1
—
LRP6
(physical association, anti bait coimmunoprecipitation)
Yamamoto et al., Dev Cell 2006
-
IRef Intact Interaction:
CAV1
—
LRP6
(colocalization, fluorescence microscopy)
Yamamoto et al., Dev Cell 2006
Text-mined interactions from Literome
Yamamoto et al., Dev Cell 2006
:
Overall, our data suggest that Wnt-3a triggers the interaction of
LRP6 with caveolin and promotes recruitment of Axin to LRP6 phosphorylated by glycogen synthase kinase-3beta and that
caveolin thereby
inhibits the binding of beta-catenin to Axin
Yamamoto et al., Dev Cell 2008
:
In this study, we found that Wnt3a acts in parallel to induce the
caveolin dependent internalization of low-density-lipoprotein receptor related protein 6 ( LRP6 ), as well as the phosphorylation of
LRP6 and the recruitment of Axin to LRP6 on the cell surface membrane