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Text-mined interactions from Literome

Linden et al., Eur Respir J 1988 : NAC also enhanced the decreased LTB4 secretion by smokers ' AMs ( p less than 0.05 )
Dent et al., Br J Pharmacol 1997 : At concentrations of 10 microM and above, NAC augmented significantly the level of LTB4 in the supernatants of OZ- and fMLP stimulated neutrophils ( P < 0.01 and P < 0.05, respectively ) and OZ-stimulated macrophages ( P < 0.05 at 10 microM, P < 0.01 at 100 microM NAC ) ... LTB4 undergoes a H2O2 dependent oxidation that is inhibited by NAC but this is unlikely to account fully for the increased levels of LTB4, suggesting that NAC may increase LTB4 production by blocking the H2O2 dependent inhibition of a synthetic enzyme, such as 5-lipoxygenase