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ILK — ITGB1

Pathways - manually collected, often from reviews:

• BioCarta pten dependent cell cycle arrest and apoptosis: Integrin-beta/SHC/SOS-1/GRB2 complex (ITGB1-SHC1-SOS1-GRB2) → ILK (modification, activates)
• KEGG Bacterial invasion of epithelial cells: ITGA5/ITGB1 → ILK (protein-protein, activation)
• Reactome Reaction: ILK → ITGB1 (reaction) Hannigan et al., Nature 1996*
• Reactome Reaction: ILK → ITGB1 (direct_complex) Hannigan et al., Nature 1996*
• WikiPathways Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling: ITGB1 → ILK (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: ITGB1 — ILK Hannigan et al., Nature 1996*
• IRef Bind_translation Interaction: ITGB1 — ILK (coimmunoprecipitation) Hannigan et al., Nature 1996*
• IRef Bind_translation Interaction: ITGB1 — ILK (two hybrid) Hannigan et al., Nature 1996*
• IRef Biogrid Interaction: ILK — ITGB1 (physical association, affinity chromatography technology) Hannigan et al., Nature 1996*
• IRef Hprd Interaction: ILK — ITGB1 (in vitro) Hannigan et al., Nature 1996*, Delcommenne et al., Proc Natl Acad Sci U S A 1998
• IRef Hprd Interaction: ILK — ITGB1 (in vivo) Hannigan et al., Nature 1996*, Delcommenne et al., Proc Natl Acad Sci U S A 1998
• IRef Intact Interaction: Complex of 400 proteins (association, cross-linking study) Humphries et al., Science signaling 2009
• IRef Ophid Interaction: ITGB1 — ILK (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: ITGB1 — ILK (aggregation, confirmational text mining) Delcommenne et al., Proc Natl Acad Sci U S A 1998

Text-mined interactions from Literome

Dogra et al., J Cell Physiol 2006 (Muscular Dystrophy, Animal) : Finally, cellular levels of Bcl-2, cIAP1, and integrin beta1 and activation of integrin linked kinase were higher in diaphragm muscle of mdx mice compared to normal mice
Camacho-Leal et al., J Cell Physiol 2007 (MAP Kinase Signaling System) : Inhibition of PI3-K and ILK , but not MAPK, prevented the alpha5beta1 integrin activation
Chen et al., Biochem Pharmacol 2008 : Astragaloside IV improves high glucose induced podocyte adhesion dysfunction via alpha3beta1 integrin upregulation and integrin linked kinase inhibition ... These results suggest that AS-IV improve HG-induced podocyte adhesion dysfunction, which is partly attributed to alpha(3)beta(1) integrin upregulation and ILK inhibition