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HMOX1 — PPARG
Text-mined interactions from Literome
Kitamura et al., Neurosci Lett 1999
:
However,
PPARgamma activator alone
induced HO-1 expression and further enhanced LPS/IFN-gamma induced HO-1 expression ... These results suggest that activation of
PPARgamma negatively regulate iNOS expression and positively
regulates HO-1 expression in glial cells
Wayman et al., FASEB J 2002
(Myocardial Infarction...) :
The mechanisms of the cardioprotective effects of 15D-PGJ2 may include 1 ) activation of PPAR-alpha, 2 )
activation of
PPAR-gamma , 3 ) expression of
HO-1 , and 4 ) inhibition of the activation of NF-kappaB in the ischemic reperfused heart
Ptasinska et al., FASEB J 2007
:
NO* mediated
PPARgamma binding and NO*
induction of cyclooxygenase-2 (COX-2), diacylglycerol (DAG) kinase alpha ( DGKalpha ), and
heme oxygenase-1 (HO-1) , genes with well characterized PPRE motifs, were cGMP independent
Krönke et al., Arterioscler Thromb Vasc Biol 2007
:
Analysis of the human HO-1 promoter in transient transfection experiments together with mutational analysis and gel shift assays revealed a direct transcriptional
regulation of
HO-1 by PPARalpha and
PPARgamma via 2 PPAR responsive elements ... We demonstrate that
HO-1 expression is transcriptionally
regulated by PPARalpha and
PPARgamma , indicating a mechanism of anti-inflammatory and antiproliferative action of PPAR ligands via upregulation of HO-1
Lim et al., Toxicol Appl Pharmacol 2007
:
In addition, ROS scavenger pretreatment suppressed 15d-PGJ ( 2 ) -induced HO-1 expression while PPARgamma antagonist did not, suggesting nuclear translocation of Nrf-2 and subsequent
HO-1 expression was ROS dependent rather than
PPARgamma dependent
O'Brien et al., Journal of thrombosis and haemostasis : JTH 2009
:
15d-PGJ ( 2 ) -induced
HO-1 was
independent of
PPARgamma , but could be replicated using other electrophilic prostaglandins, suggesting that the electrophilic properties of 15d-PGJ ( 2 ) were important for HO-1 induction
Ferguson et al., Am J Physiol Lung Cell Mol Physiol 2009
:
We report here that the
PPARgamma ligands 15d-PGJ2 and 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid ( CDDO ), which have potent antifibrotic effects in vitro, also strongly
induce HO-1 expression in primary human lung fibroblasts
Li et al., FEBS J 2010
:
Taken together, our findings suggest that activation of
PPARgamma induces
HO-1 expression, and that this in turn stimulates p21 ( WAF1 ) expression to suppress PASMC proliferation