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HIF1A — RPTOR
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Toschi et al., J Biol Chem 2008
:
HIF1 alpha expression was
dependent on both
Raptor ( a constituent of mTORC1 ) and Rictor ( a constitutive of mTORC2 ) ... These data indicate that although
HIF1 alpha is
dependent on both
mTORC1 and mTORC2, HIF2 alpha is dependent only on mTORC2
Pistollato et al., PloS one 2009
(Brain Neoplasms...) :
Here, we investigate the
role of
mTOR signaling in the regulation of
HIF-1alpha stability in primary GBM derived cells maintained under hypoxia ( 2 % oxygen )
Ji et al., Mol Pharmacol 2010
:
Stimulation of endogenous EP1 receptors in human HepG2 hepatocellular carcinoma cells recapitulated the normoxic up-regulation of
HIF-1 alpha observed in HEK cells, was sensitive to pertussis toxin, and
involved the activation of
mTOR signaling and phosphorylation of rpS6