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MAP2K1 — SLC22A3

Text-mined interactions from Literome

Lemieux et al., Int J Cancer 2009 (Cell Transformation, Neoplastic...) : However, the role of MEK1 in intestinal EMT , tumor invasion and metastasis has not been elucidated ... In conclusion, our results demonstrate, for the first time, that constitutive activation of MEK1 in intestinal epithelial cells is sufficient to induce an EMT associated with tumor invasion and metastasis
Chen et al., Exp Cell Res 2010 : Inhibition of mitogen activated protein kinase kinase 1 ( MEK 1 ) either directly with PD98059 or with MEK 1 siRNA resulted in inhibition of EPO mediated suppression of EMT and Smad signal transduction in TGF-beta1 treated cells
Amatangelo et al., Carcinogenesis 2012 (Prostatic Neoplasms) : Mechanistic studies revealed that in cells stably transfected with activated Ras, TGF-ß alone induced EMT and that a Ras-Raf-MEK1 , but not MEK2, signaling cascade is necessary and sufficient for Erk2 nuclear localization that works in concert with TGF-ß to promote EMT