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GAL — TLR2
Text-mined interactions from Literome
Kammanadiminti et al., FASEB J 2004
:
Regulation of
Toll-like receptor-2 expression by the
Gal-lectin of Entamoeba histolytica ... The mechanism whereby the
Gal-lectin regulates
Toll-like receptor 2 (TLR-2) expression in macrophages was studied ... Native
Gal-lectin increased
TLR-2 mRNA expression in a dose- and time dependent fashion ; peak response occurred with 1 microg/ml after 2 h stimulation ... The Gal-lectin increased TLR-2 gene transcription, and the half-life of the mRNA transcripts was 1.4 h. Inhibition of nuclear factor (NF)-kappaB suppressed
TLR-2 mRNA
induction by the
Gal-lectin
Darmoise et al., Immunity 2010
:
Thus, we present
TLR dependent negative regulation of
alpha-Gal-A as a mechanistic link between pathogen recognition and self lipid antigen induction for NKT cells