Gene interactions and pathways from curated databases and text-mining

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IL8 — TAB1

Text-mined interactions from Literome

Channavajhala et al., J Biol Chem 2003 (MAP Kinase Signaling System) : Moreover, Cot induced interleukin-8 production in HeLa cells is almost completely inhibited by the concurrent expression of hKSR-2, whereas transforming growth factor beta activated kinase 1 ( TAK1 ) /TAK1 binding protein 1 (TAB1) induced interleukin-8 production is not affected by hKSR-2 co-expression
Frobøse et al., Mol Endocrinol 2006 : Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex
Thiefes et al., EMBO Rep 2006 : YopP, but not the catalytically inactive mutant YopP ( C172A ), also suppresses basal and interleukin-1-inducible activation of endogenous TAK1, TAB1 and TAB2 ... YopP, but not the catalytically inactive mutant YopP ( C172A ), also suppresses basal and interleukin-1-inducible activation of endogenous TAK1, TAB1 and TAB2 ... YopP, but not the catalytically inactive mutant YopP ( C172A ), also suppresses basal and interleukin-1-inducible activation of endogenous TAK1 , TAB1 and TAB2
Zhou et al., World J Gastroenterol 2008 (Adenocarcinoma...) : Viable LBG or LBG- ( s ) pretreatment attenuated the expression of TLR4, inhibited the phosphorylation of TAK1 and p38MAPK, prevented the activation of NF-kappaB, and consequently blocked IL-8 production
Kim et al., PloS one 2009 (Colitis) : Finally, we showed that TAK1 is essential for interleukin 1- and bacterial components induced expression of cytoprotective factors such as interleukin 6 and cycloxygenase 2
Pera et al., Am J Physiol Lung Cell Mol Physiol 2012 (MAP Kinase Signaling System) : In addition, inhibitors of TAK1 and the NF-?B ( SC-514 ; 50 µM ) and ERK-1/2 ( U-0126 ; 3 µM ) signaling inhibited the CSE induced IL-8 release by ASM cells ... These data indicate that TAK1 plays a major role in CSE induced ERK-1/2 and NF-?B signaling and in IL-8 release by human ASM cells