Gene interactions and pathways from curated databases and text-mining

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BRCA1 — RAD50

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Paull et al., Proc Natl Acad Sci U S A 2001 : As a result of this binding, Brca1 inhibits the nucleolytic activities of the Mre11/Rad50/Nbs1 complex , an enzyme implicated in numerous aspects of double-strand break repair
Yang et al., PloS one 2008 (Adenocarcinoma...) : Oncogenic K-ras induced BASC accumulation and tumor growth were blocked by treatment with a small molecule PI3K inhibitor and enhanced by inactivation of phosphatase and tensin homologue deleted from chromosome 10, a negative regulator of PI3K
Dovey et al., Proc Natl Acad Sci U S A 2008 (Cell Transformation, Neoplastic...) : Abrogated lung cancer development and BASC self-renewal occur partially in a p19(ARF) dependent manner
Ballal et al., J Biol Chem 2009 : Our findings further suggest that Rad50 is required to localize BRCA1 at the telomere and that the association of BRCA1 with Rad50 does not require DNA ... Our findings suggest that BRCA1 is recruited to the telomere in a Rad50 dependent manner and that BRCA1 may regulate telomere length and stability, in part through its presence at the telomere